Intravenous leiomyomatosis with intracardiac extension: a single-institution experience

• Published in: American journal of obstetrics and gynecology Vol. 201; no. 6; pp. 574.e1 - 574.e5
• Main Authors: Worley, Micheal J., MD, Aelion, Anate, MD, Caputo, Thomas A., MD, Kent, Kenneth C., MD, Salemi, Arash, MD, Krieger, Karl H., MD, Goldstein, Michael J., MD, Kuo, Dennis Y., MD, Slomovitz, Brian M., MD
• Format: Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 01.12.2009; Elsevier
• Subjects: Adult; Biological and medical sciences; cardiac mass; Female; fibroid; Gynecology. Andrology. Obstetrics; Heart Neoplasms - secondary; Heart Neoplasms - surgery; Humans; intravenous leiomyomatosis; Leiomyomatosis - pathology; Leiomyomatosis - surgery; Medical sciences; Middle Aged; Neoplasm Invasiveness; Obstetrics and Gynecology; Retrospective Studies; Treatment Outcome; Vascular Neoplasms - pathology; Vascular Neoplasms - surgery; cardiac mass; fibroid; intravenous leiomyomatosis; Heart; Extension; Intravenous administration; Gynecology; Leiomyomata; Benign neoplasm; Institution; Obstetrics
• ISSN: 0002-9378; 1097-6868
• DOI: 10.1016/j.ajog.2009.06.037

Objective The aim of this study was to outline the surgical management and outcomes for patients diagnosed with intravenous leiomyomatosis with intracardiac extension at a single institution. Study Design This was a retrospective review of patients diagnosed with intravenous leiomyomatosis with intracardiac extension between 2002–2008. Results Four patients were identified. The surgical approach in 3 (75%) patients was a single-stage operation. Four (100%) patients presented with cardiac symptoms: 3 (75%) with syncope and 1 (25%) with an abnormal electrocardiogram. Mean age at presentation was 48 years (range, 42–58 years). Complete resection of tumor was obtained in 1 (25%) patient and 3 (75%) patients experienced incomplete resection. Mean follow-up, including surveillance imaging, was 25.5 months (range, 8–57 months) and all 4 patients (100%) are currently free of recurrence. Conclusion Surgical excision remains an effective therapy for treating patients with benign metastasizing leiomyomatosis. Incomplete surgical resection may result in favorable response.