Vegetative chronic genital herpes with satisfactory response to imiquimod

• Published in: Anais brasileiros de dermatología Vol. 94; no. 2; pp. 221 - 223
• Main Authors: Siqueira, Stella Meireles, Gonçalves, Bruna Barroso, Loss, Julia Bozetti, Estrella, Rogerio Ribeiro
• Format: Journal Article
• Language: English; Portuguese
• Published: Spain Elsevier España, S.L.U 01.03.2019; Sociedade Brasileira de Dermatologia
• Subjects: Adjuvants, Immunologic - administration & dosage; Adjuvants, Immunologic - therapeutic use; Adult; AIDS-Related Opportunistic Infections - drug therapy; Antiviral agents; Case Report; Chronic Disease; DERMATOLOGY; Dose-Response Relationship, Drug; Drug therapy; Efficacy; Herpes genitalis; Herpes Genitalis - diagnosis; Herpes Genitalis - drug therapy; Herpes simplex; Humans; Imiquimod - administration & dosage; Imiquimod - therapeutic use; Male; Therapeutics; Treatment Outcome; Herpes simplex; Antiviral agents; Herpes genitalis; Efficacy; Drug therapy; Therapeutics
• ISSN: 0365-0596; 1806-4841; 1806-4841
• DOI: 10.1590/abd1806-4841.20198014

Vegetative chronic genital herpes is an atypical presentation of herpes simplex 2 that it is usually seen in patients coinfected with human immunodeficiency virus. Clinically, it is characterized by extensive ulcers that evolve to chronification and hypertrophic pseudotumor forms. Antiviral drugs are recommended for the treatment, and acyclovir is the most used one. Foscarnet is the treatment of choice to resistant cases, although treatment failure has been reported. We report a male patient, previously diagnosed with human immunodeficiency virus who developed vegetative chronic genital herpes resistant to acyclovir and successfully treated with imiquimod.