Antibody avidity following secondary dengue virus type 2 infection across a range of disease severity

Highlights • We studied antibody avidity kinetics relative to disease severity post-secondary DENV2 infection. • Avidity increased between acute and convalescence and stabilized from 3 to 18 months post-illness. • Sera from DHF/DSS cases had lower avidity at 18 months post-illness than DF cases. • A...

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Bibliographic Details
Published inJournal of clinical virology Vol. 69; pp. 63 - 67
Main Authors Lau, Louis, Green, Angela M, Balmaseda, Angel, Harris, Eva
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.08.2015
Subjects
Adolescent
Allergy and Immunology
Antibodies, Viral - blood
Antibody Affinity
Antibody avidity
Child
Child, Preschool
Coinfection - immunology
Dengue - immunology
Dengue - virology
Dengue hemorrhagic fever/dengue shock syndrome
Dengue virus
Dengue Virus - classification
Dengue Virus - immunology
Dengue virus type 2
Disease severity
Enzyme-Linked Immunosorbent Assay
Female
Humans
Immunoglobulin G - blood
Infant
Infectious Disease
Male
Nicaragua
Serogroup
Severe Dengue - immunology
Severe Dengue - virology
Nicaragua
ASW, Nicaragua
Disease severity
Antibody avidity
Dengue virus
Dengue hemorrhagic fever/dengue shock syndrome
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Summary:Highlights • We studied antibody avidity kinetics relative to disease severity post-secondary DENV2 infection. • Avidity increased between acute and convalescence and stabilized from 3 to 18 months post-illness. • Sera from DHF/DSS cases had lower avidity at 18 months post-illness than DF cases. • A faster rate of decay in avidity was observed in DHF/DSS compared to DF cases. • Severe dengue was associated with lower antibody avidity at later times post-illness.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1386-6532
1873-5967
DOI:10.1016/j.jcv.2015.06.003