MicroRNA Regulation of Cancer Stem Cells

Cancer stem cells (CSC), or cancer cells with stem cell properties, have been reported in many human tumors and are thought to be responsible for tumor initiation, therapy resistance, progression, relapse, and metastasis. Despite their potential clinical importance, how CSCs are regulated at the mol...

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Bibliographic Details
Published inCancer research (Chicago, Ill.) Vol. 71; no. 18; pp. 5950 - 5954
Main Authors CAN LIU, TANG, Dean G
Format Journal Article
LanguageEnglish
Published Philadelphia, PA American Association for Cancer Research 15.09.2011
Subjects
Animals
Antineoplastic agents
Biological and medical sciences
Cancer
CD44 antigen
Humans
Medical sciences
Metastases
MicroRNAs - physiology
miRNA
Neoplastic Stem Cells - physiology
Pharmacology. Drug treatments
Prostate
Reviews
Stem cells
Tumors
Gene silencing
Regulation(control)
RNA interference
Stem cell
Micro RNA
Molecular biology
Tumor cell
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Summary:Cancer stem cells (CSC), or cancer cells with stem cell properties, have been reported in many human tumors and are thought to be responsible for tumor initiation, therapy resistance, progression, relapse, and metastasis. Despite their potential clinical importance, how CSCs are regulated at the molecular level is not well understood. MicroRNAs (miRNA), small noncoding RNAs that play critical roles in normal stem cell functions during development, have emerged as important regulators of CSCs as well. In this review, we summarize the current major findings of miRNA regulation of various CSCs and discuss our recent findings that miR-34a suppresses prostate CSCs and metastasis by directly repressing CD44. This recent progress has important implications for understanding how CSCs are intricately regulated by networks of miRNAs and for developing novel mechanism-based miRNA therapeutics that specifically target CSCs.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
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ISSN:0008-5472
1538-7445
DOI:10.1158/0008-5472.can-11-1035