Current status of cell-mediated regenerative therapies for human spinal cord injury

During the past decade, significant advances have been made in refinements for regenerative therapies following human spinal cord injury （SCI）. Positive results have been achieved with different types of cells in various clinical studies of SCI. In this review, we summarize recently-completed clinic...

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Published inNeuroscience bulletin Vol. 30; no. 4; pp. 671 - 682
Main Authors Zhu, Tongming, Tang, Qisheng, Gao, Huasong, Shen, Yiwen, Chen, Luping, Zhu, Jianhong
Format Journal Article
LanguageEnglish
Published Heidelberg Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences 01.08.2014
Subjects
Anatomy
Anesthesiology
Biomedical and Life Sciences
Biomedicine
Clinical Trials as Topic
Human Physiology
Humans
Mesenchymal Stem Cell Transplantation
Mesenchymal Stromal Cells - physiology
Nerve Regeneration - physiology
Neural Stem Cells - physiology
Neurology
Neurosciences
Pain Medicine
Review
Spinal Cord Injuries - therapy
临床试验
人类
介导
再生
状态
疗法
神经干细胞
脊髓损伤
spinal cord injury
cell-mediated regenerative therapy
clinical trials
stem cell
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Summary:During the past decade, significant advances have been made in refinements for regenerative therapies following human spinal cord injury （SCI）. Positive results have been achieved with different types of cells in various clinical studies of SCI. In this review, we summarize recently-completed clinical trials using cell- mediated regenerative therapies for human SCI, together with ongoing trials using neural stem cells. Specifically, clinical studies published in Chinese journals are included. These studies show that current transplantation therapies are relatively safe, and have provided varying degrees of neurological recovery. However, many obstacles exist, hindering the introduction of a specific clinical therapy, including complications and their causes, selection of the target population, and optimization of transplantation material. Despite these and other challenges, with the collaboration of research groups and strong support from various organizations, cell-mediated regenerative therapies will open new perspectives for SCI treatment.
Bibliography:During the past decade, significant advances have been made in refinements for regenerative therapies following human spinal cord injury （SCI）. Positive results have been achieved with different types of cells in various clinical studies of SCI. In this review, we summarize recently-completed clinical trials using cell- mediated regenerative therapies for human SCI, together with ongoing trials using neural stem cells. Specifically, clinical studies published in Chinese journals are included. These studies show that current transplantation therapies are relatively safe, and have provided varying degrees of neurological recovery. However, many obstacles exist, hindering the introduction of a specific clinical therapy, including complications and their causes, selection of the target population, and optimization of transplantation material. Despite these and other challenges, with the collaboration of research groups and strong support from various organizations, cell-mediated regenerative therapies will open new perspectives for SCI treatment.
Tongming Zhu, Qisheng Tang, Huasong Gao, Yiwen Shen, Luping Chen, Jianhong Zhu （Department of Neurosurgery, Fudan University Huashan Hospital, National Key Laboratory of Medical Neurobiology, Institutes of Brain Science, Shanghai Medical College, Fudan University, Shanghai 200040, China）
cell-mediated regenerative therapy; spinal cord injury; clinical trials; stem cell
31-1975/R
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1673-7067
1995-8218
DOI:10.1007/s12264-013-1438-4