Function and assembly of the Leishmania surface coat

Like many trypanosomatids, the cell surface coat of Leishmania spp. is responsible for mediating various host–parasite interactions as well as acting as a dense physical barrier. This confers protection to the parasites in the hostile environments of the sandfly midgut and the macrophage phagolysoso...

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Published inInternational Journal for Parasitology Vol. 31; no. 9; pp. 899 - 908
Main Authors Ilgoutz, Steven C, McConville, Malcolm J
Format Book Review Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.07.2001
Subjects
Animals
Biosynthesis
Gene Expression Regulation - physiology
Gene knockout
Glycocalyx
Glycolipid
Glycosylation
Glycosylphosphatidylinositol
Glycosylphosphatidylinositols - biosynthesis
Glycosylphosphatidylinositols - physiology
Leishmania
Leishmania - genetics
Leishmania - metabolism
Leishmania - physiology
Metalloendopeptidases - biosynthesis
Metalloendopeptidases - genetics
Metalloendopeptidases - physiology
surface coat
Glycocalyx
Glycosylphosphatidylinositol
Biosynthesis
Gene knockout
Leishmania
Glycolipid
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Summary:Like many trypanosomatids, the cell surface coat of Leishmania spp. is responsible for mediating various host–parasite interactions as well as acting as a dense physical barrier. This confers protection to the parasites in the hostile environments of the sandfly midgut and the macrophage phagolysosome. The major components of the surface coat are tethered to the cell surface via glycosylphosphatidylinositol glycolipids, and the composition of this surface coat is exquisitely regulated during the course of the parasite life-cycle. In this paper, we review what is known about the composition, biosynthesis and function of these glycosylphosphatidylinositol-containing molecules found within the parasite surface coat.
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ISSN:0020-7519
1879-0135
DOI:10.1016/S0020-7519(01)00197-7