Improvement of Osseointegration by Ultraviolet and/or Simvastatin Treatment on Titanium Implants with or without Bone Graft Materials

• Published in: Materials Vol. 14; no. 13; p. 3707
• Main Authors: Jun, Ji Hoon, Oh, Kyung Chul, Park, Kyu-Hyung, Jung, Narae, Li, Jiayi, Moon, Hong Seok
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.07.2021; MDPI
• Subjects: animal experiments; Antilipemic agents; bone implant interactions; bone regeneration; bone substitutes; Bones; Collagen; Comparative analysis; Dental implants; Dental materials; Grafting; Grafts; illumination; Implant dentures; Infrared analysis; Infrared spectrometers; Rabbits; Simvastatin; Skin & tissue grafts; statin; Submerging; Substitute bone; Surface treatment; Surgical implants; Tibia; Titanium; Transplants & implants; Ultraviolet radiation; South Korea; Germany; United States > US; bone substitutes; illumination; statin; bone implant interactions; titanium; animal experiments; bone regeneration
• ISSN: 1996-1944; 1996-1944
• DOI: 10.3390/ma14133707

We evaluated and compared ultraviolet (UV) treatment and simvastatin (SIM) immersion effects on the osseointegration of sandblasted, large-grit, acid-etched (SLA) titanium dental implants at two different time points in rabbit tibias, with or without xenogenic bone graft materials. The surface alteration on simvastatin treatment titanium discs was analyzed using an infrared spectrometer. Implants were categorized into four groups according to the surface treatment type. Twelve rabbits received two implants per tibia. A tibial defect model was created using a trephine bur, with implants in contact with the bone surface and bovine bone graft materials for gap filling. The rabbits were sacrificed after 2 or 4 weeks. UV treatment or SIM immersion increased the bone-to-implant contact (BIC) on nongrafted sides, and both increased the BIC and bone area (BA) on grafted sides. The application of both treatments did not result in higher BIC or BA than a single treatment. At two different time points, BIC in the nongrafted sides did not differ significantly among the UV and/or SIM treated groups, whereas BA differed significantly. UV or SIM treatment of SLA titanium implants accelerates osseointegration in tibias with or without xenogenic bone graft materials. The combination of both treatments did not show synergy.