Gut Microbiota Profile in Adults Undergoing Bariatric Surgery: A Systematic Review

• Published in: Nutrients Vol. 14; no. 23; p. 4979
• Main Authors: Coimbra, Vívian O R, Crovesy, Louise, Ribeiro-Alves, Marcelo, Faller, Ana Luísa K, Mattos, Fernanda, Rosado, Eliane L
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 23.11.2022; MDPI
• Subjects: Adults; Analysis; Bacteria; Bacteria - genetics; bariatric surgery; Bariatric Surgery - methods; Body mass index; Body weight loss; Care and treatment; Clinical trials; Digestive system; Digestive tract; Fatty acids; Food; Gastrectomy; Gastrectomy - methods; Gastric bypass; Gastric Bypass - methods; Gastrointestinal Microbiome; Gastrointestinal surgery; Gastrointestinal system; gut microbiota; Health aspects; Humans; Intestinal microflora; Metabolism; Metabolites; Metagenomics; Microbiota; Microbiota (Symbiotic organisms); Obesity; Obesity, Morbid - surgery; Physiological aspects; Physiology; Postoperative period; Review; RNA, Ribosomal, 16S; rRNA 16S; Surgery; Systematic review; Treatment Outcome; Type 2 diabetes; Weight control; Weight loss; Womens health; Brazil; gut microbiota; obesity; bariatric surgery
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu14234979

Gut microbiota (GM) after bariatric surgery (BS) has been considered as a factor associated with metabolic improvements and weight loss. In this systematic review, we evaluate changes in the GM, characterized by 16S rRNA and metagenomics techniques, in obese adults who received BS. The PubMed, Scopus, Web of Science, and LILACS databases were searched. Two independent reviewers analyzed articles published in the last ten years, using Rayyan QCRI. The initial search resulted in 1275 documents, and 18 clinical trials were included after the exclusion criteria were applied. The predominance of intestinal bacteria phyla varied among studies; however, most of them reported a greater amount of (B), (P), and diversity (D) after BS. (F), B, and the (F/B) ratio was inconsistent, increasing or decreasing after Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) were conducted, compared to before surgery. There was a reduction in the relative proportion of F. Moreover, a higher proportion of (A) was observed after RYGB was conducted. However, the same was not identified when SG procedures were applied. Genera abundance and bacteria predominance varied according to the surgical procedure, with limited data regarding the impact on phyla. The present study was approved by PROSPERO, under registration number CRD42020209509.