Daunomycin-loaded superparamagnetic iron oxide nanoparticles: Preparation, magnetic targeting, cell cytotoxicity, and protein delivery research

The clinical use of daunomycin is restricted by dose-dependent toxicity and low specificity against cancer cells. In the present study, modified superparamagnetic iron oxide nanoparticles were employed to load daunomycin and the drug-loaded nanospheres exhibited satisfactory size and smart pH-respon...

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Bibliographic Details
Published inJournal of biomaterials applications Vol. 31; no. 2; p. 261
Main Authors Liu, Min-Chao, Jin, Shu-Fang, Zheng, Min, Wang, Yan, Zhao, Peng-Liang, Tang, Ding-Tong, Chen, Jiong, Lin, Jia-Qi, Wang, Xia-Hong, Zhao, Ping
Format Journal Article
LanguageEnglish
Published England 01.08.2016
Subjects
Cell Survival
Daunorubicin - pharmacology
Doxorubicin - chemistry
Drug Delivery Systems
Drug Liberation
Ferric Compounds - chemistry
HeLa Cells
Humans
Magnetite Nanoparticles - chemistry
Microscopy, Electron, Scanning
Microscopy, Electron, Transmission
Molecular Docking Simulation
Nanospheres - chemistry
Serum Albumin - chemistry
interaction
carrier protein
Daunomycin
conformation
superparamagnetic iron oxide nanoparticle
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Summary:The clinical use of daunomycin is restricted by dose-dependent toxicity and low specificity against cancer cells. In the present study, modified superparamagnetic iron oxide nanoparticles were employed to load daunomycin and the drug-loaded nanospheres exhibited satisfactory size and smart pH-responsive release. The cellular uptake efficiency, targeted cell accumulation, and cell cytotoxicity experimental results proved that the superparamagnetic iron oxide nanoparticle-loading process brings high drug targeting without decreasing the cytotoxicity of daunomycin. Moreover, a new concern for the evaluation of nanophase drug delivery's effects was considered, with monitoring the interactions between human serum albumin and the drug-loaded nanospheres. Results from the multispectroscopic techniques and molecular modeling calculation elucidate that the drug delivery has detectable deleterious effects on the frame conformation of protein, which may affect its physiological function.
ISSN:1530-8022
DOI:10.1177/0885328216654425