Memory Enhancement and Deep-Brain Stimulation of the Entorhinal Area

Subjects underwent deep-brain stimulation through electrodes implanted to identify the foci of their epileptic seizures. The efficiency with which they navigated a virtual environment supports the conclusion that deep-brain stimulation improved memory in these persons. Loss of the ability to remembe...

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Published inThe New England journal of medicine Vol. 366; no. 6; pp. 502 - 510
Main Authors Suthana, Nanthia, Haneef, Zulfi, Stern, John, Mukamel, Roy, Behnke, Eric, Knowlton, Barbara, Fried, Itzhak
Format Journal Article
LanguageEnglish
Published Waltham, MA Massachusetts Medical Society 09.02.2012
Subjects
Biological and medical sciences
Brain
Brain research
Cortex (entorhinal)
Cortex (temporal)
Deep Brain Stimulation
EEG
Electrical stimuli
Electrodes
Electrodes, Implanted
Electroencephalography
Entorhinal Cortex
Epilepsy
Epilepsy - surgery
General aspects
Hippocampus
Humans
Intelligence
Learning
Magnetic Resonance Imaging
Medical sciences
Memory
NMR
Nuclear magnetic resonance
Seizures
Spatial Behavior
Spatial discrimination learning
Spatial memory
Surgery
Medicine
Brain
Stimulation
Memory
Central nervous system
Encephalon
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Summary:Subjects underwent deep-brain stimulation through electrodes implanted to identify the foci of their epileptic seizures. The efficiency with which they navigated a virtual environment supports the conclusion that deep-brain stimulation improved memory in these persons. Loss of the ability to remember is one of the most dreaded afflictions of the human condition. Decades of research and clinical observations have established that declarative memory, the ability to remember recently experienced facts and events, depends on the hippocampus and associated structures in the medial temporal lobe, including the entorhinal, perirhinal, and parahippocampal cortexes. 1 Deep-brain stimulation has emerged as a technique to treat neurologic and neuropsychiatric disorders, including Parkinson's disease, dystonia, depression, and obsessive–compulsive disorder. 2 – 5 The nature of the stimulation-induced modification of the neural circuit that results in improvement in patients with these disorders is not completely . . .
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ISSN:0028-4793
1533-4406
1533-4406
DOI:10.1056/NEJMoa1107212