Domestic Waste and Wastewaters as Potential Sources of Pharmaceuticals in Nestling White Storks ( Ciconia ciconia )

• Published in: Antibiotics (Basel) Vol. 12; no. 3; p. 520
• Main Authors: Blanco, Guillermo, Gómez-Ramírez, Pilar, Espín, Silvia, Sánchez-Virosta, Pablo, Frías, Óscar, García-Fernández, Antonio J
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 05.03.2023; MDPI
• Subjects: Acetaminophen; Analgesics; Antibiotics; Aquatic birds; Blood; Cattle; Ciconia ciconia; Drugs; ecopharmacovigilance; Evaluation; Exposure; Feeds; Food consumption; Food contamination & poisoning; Foraging behavior; Gels; Household wastes; human medicines; Human populations; Instrument industry; Juveniles; Landfill; Landfills; Literature reviews; Livestock; Meat; Metabolites; Municipal waste management; Nests; Nonsteroidal anti-inflammatory drugs; Offspring; pharmaceutical pollution; Pharmaceuticals; Pollutants; Refuse and refuse disposal; rubbish dumps; Sewage treatment plants; Solid wastes; veterinary drugs; Veterinary medicine; Vultures; Wastewater; Water pollution; wildlife; United States; Spain; pharmaceutical pollution; human medicines; veterinary drugs; ecopharmacovigilance; rubbish dumps; wildlife
• ISSN: 2079-6382; 2079-6382
• DOI: 10.3390/antibiotics12030520

Information on the exposure of wild birds to pharmaceuticals from wastewater and urban refuse is scarce despite the enormous amount of drugs consumed and discarded by human populations. We tested for the presence of a battery of antibiotics, NSAIDs, and analgesics in the blood of white stork ( ) nestlings in the vicinity of urban waste dumps and contaminated rivers in Madrid, central Spain. We also carried out a literature review on the occurrence and concentration of the tested compounds in other wild bird species to further evaluate possible shared exposure routes with white storks. The presence of two pharmaceutical drugs (the analgesic acetaminophen and the antibiotic marbofloxacin) out of fourteen analysed in the blood of nestlings was confirmed in 15% of individuals ( = 20) and in 30% of the nests ( = 10). The apparently low occurrence and concentration (acetaminophen: 9.45 ng mL ; marbofloxacin: 7.21 ng mL ) in nestlings from different nests suggests the uptake through food acquired in rubbish dumps rather than through contaminated flowing water provided by parents to offspring. As with other synthetic materials, different administration forms (tablets, capsules, and gels) of acetaminophen discarded in household waste could be accidentally ingested when parent storks forage on rubbish to provide meat scraps to their nestlings. The presence of the fluoroquinolone marbofloxacin, exclusively used in veterinary medicine, suggests exposure via consumption of meat residues of treated animals for human consumption found in rubbish dumps, as documented previously at higher concentrations in vultures consuming entire carcasses of large livestock. Control measures and ecopharmacovigilance frameworks are needed to minimize the release of pharmaceutical compounds from the human population into the environment.