Dietary Supplementation of Cedryl Acetate Ameliorates Adiposity and Improves Glucose Homeostasis in High-Fat Diet-Fed Mice

• Published in: Nutrients Vol. 15; no. 4; p. 980
• Main Authors: Guo, Jingya, Li, Mengjie, Zhao, Yuhan, Kang, Seong-Gook, Huang, Kunlun, Tong, Tao
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.02.2023; MDPI
• Subjects: Acetates - pharmacology; Acetic acid; Adipocytes; Adipose tissue; Adiposity; Animals; Body fat; Body weight gain; cedryl acetate; Complications and side effects; Diet; Diet therapy; Diet, High-Fat; Dietary Supplements; Discriminant analysis; Gene expression; Gluconeogenesis; Glucose; Glucose - metabolism; Glucose tolerance; gut microbiota; Health aspects; High fat diet; Homeostasis; Hypertrophy; Insulin; Insulin resistance; Intestinal microflora; Intolerance; Lipids; Metabolic diseases; Metabolic disorders; Metabolic syndrome; Metabolic Syndrome - complications; Mice; Mice, Inbred C57BL; Microbiota; Natural products; Obesity; Obesity - metabolism; Phytochemicals; Risk factors; RNA, Ribosomal, 16S - metabolism; rRNA 16S; Sesquiterpenes; Weight reduction; China; Beijing China; United States > US; cedryl acetate; gut microbiota; obesity; high-fat diet
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu15040980

Cedryl acetate (CA), also called acetyl cedrene, is approved by the FDA as a flavoring or adjuvant to be added to foods. In this study, we aimed to investigate the preventive benefits of CA on obesity and obesity-related metabolic syndrome caused by a high-fat diet (HFD). Three groups of C57BL/6J mice (ten-week-old) were fed Chow, an HFD, or an HFD with CA supplementation (100 mg/kg) for 19 weeks. We observed that CA supplementation significantly reduced weight gain induced by an HFD, decreased the weight of the visceral fat pads, and prevented adipocyte hypertrophy in mice. Moreover, mice in the CA group showed significant improvements in hepatic lipid accumulation, glucose intolerance, insulin resistance, and gluconeogenesis compared with the mice in the HFD group. Since 16S rRNA analysis revealed that the gut microbiota in the CA and HFD groups were of similar compositions at the phylum and family levels, CA may have limited effects on gut microbiota in HFD-fed mice. The beneficial effects on the metabolic parameters of CA were reflected by CA's regulation of metabolism-related gene expression in the liver (including , , and ) and the epididymal white adipose tissues (including , , , , , , , and ) of the mice. In summary, a potent preventive effect of CA on HFD-induced obesity and related metabolic syndrome was highlighted by our results, and CA could be a promising dietary component for obesity intervention.