Preliminary report: Zn-alpha2-glycoprotein genotype and serum levels are associated with serum lipids
Abstract Zn-alpha2-glycoprotein (ZAG) is a serum protein implicated in cancer cachexia and lipolysis. Our aim was to investigate serum levels of ZAG and polymorphisms in the ZAG gene in relation to serum lipids in man. Serum levels of ZAG correlated with serum levels of cholesterol ( P = .00088) in...
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| Published in | Metabolism, clinical and experimental Vol. 59; no. 9; pp. 1316 - 1318 |
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| Main Authors | , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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Elsevier Inc
01.09.2010
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| Abstract | Abstract Zn-alpha2-glycoprotein (ZAG) is a serum protein implicated in cancer cachexia and lipolysis. Our aim was to investigate serum levels of ZAG and polymorphisms in the ZAG gene in relation to serum lipids in man. Serum levels of ZAG correlated with serum levels of cholesterol ( P = .00088) in healthy subjects and during weight loss ( P = .059). The ZAG genotype was associated with total cholesterol ( P = .014) and low-density lipoprotein cholesterol ( P = .026) in healthy subjects, and the associations were replicated in an additional cohort ( P = .0017 and P = .060, respectively). Our data indicate that ZAG plays a role in lipid metabolism. |
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| AbstractList | Zn-alpha2-glycoprotein (ZAG) is a serum protein implicated in cancer cachexia and lipolysis. Our aim was to investigate serum levels of ZAG and polymorphisms in the ZAG gene in relation to serum lipids in man. Serum levels of ZAG correlated with serum levels of cholesterol (
P = .00088) in healthy subjects and during weight loss (
P = .059). The ZAG genotype was associated with total cholesterol (
P = .014) and low-density lipoprotein cholesterol (
P = .026) in healthy subjects, and the associations were replicated in an additional cohort (
P = .0017 and
P = .060, respectively). Our data indicate that ZAG plays a role in lipid metabolism. Zn-alpha2-glycoprotein (ZAG) is a serum protein implicated in cancer cachexia and lipolysis. Our aim was to investigate serum levels of ZAG and polymorphisms in the ZAG gene in relation to serum lipids in man. Serum levels of ZAG correlated with serum levels of cholesterol (P = .00088) in healthy subjects and during weight loss (P = .059). The ZAG genotype was associated with total cholesterol (P = .014) and low-density lipoprotein cholesterol (P = .026) in healthy subjects, and the associations were replicated in an additional cohort (P = .0017 and P = .060, respectively). Our data indicate that ZAG plays a role in lipid metabolism. Abstract Zn-alpha2-glycoprotein (ZAG) is a serum protein implicated in cancer cachexia and lipolysis. Our aim was to investigate serum levels of ZAG and polymorphisms in the ZAG gene in relation to serum lipids in man. Serum levels of ZAG correlated with serum levels of cholesterol ( P = .00088) in healthy subjects and during weight loss ( P = .059). The ZAG genotype was associated with total cholesterol ( P = .014) and low-density lipoprotein cholesterol ( P = .026) in healthy subjects, and the associations were replicated in an additional cohort ( P = .0017 and P = .060, respectively). Our data indicate that ZAG plays a role in lipid metabolism. |
| Author | Jacobson, Peter Sjöström, Lars Eriksson, Per Olofsson, Louise E Carlsson, Björn Hale, Laura P Carlsson, Lena M.S Gummesson, Anders Hamsten, Anders Jernås, Margareta Thelle, Dag S Olsson, Bob Lystig, Theodore Sjöholm, Kajsa |
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| Cites_doi | 10.1210/jc.2009-0764 10.1159/000177086 10.1210/jc.2009-0058 10.1016/j.jsb.2004.04.009 10.1073/pnas.0308647100 10.1007/s11010-007-9447-0 10.1016/j.clinbiochem.2007.11.010 10.1016/S0022-2275(20)36728-6 10.1210/jc.2009-0758 10.1016/j.febslet.2006.12.047 10.2337/diabetes.52.8.2175 10.1016/S0022-2275(20)37830-5 10.1111/j.1365-2796.2005.01561.x 10.1074/jbc.C100301200 |
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| References_xml | – volume: 7 start-page: 846 year: 2001 end-page: 853 ident: bib6 article-title: Zinc alpha-2-glycoprotein is expressed by malignant prostatic epithelium and may serve as a potential serum marker for prostate cancer publication-title: Clin Cancer Res contributor: fullname: Sanchez – year: 2009 ident: bib9 article-title: Circulating and adipose tissue gene expression of zinc-{alpha}2-glycoprotein in obesity: its relationship with adipokine and lipolytic gene markers in subcutaneous and visceral fat publication-title: J Clin Endocrinol Metab contributor: fullname: Escote – volume: 276 start-page: 35008 year: 2001 end-page: 35013 ident: bib13 article-title: Hydrophobic ligand binding by Zn-alpha 2-glycoprotein, a soluble fat-depleting factor related to major histocompatibility complex proteins publication-title: J Biol Chem contributor: fullname: Cooper – volume: 101 start-page: 2500 year: 2004 end-page: 2505 ident: bib1 article-title: Zinc-alpha2-glycoprotein, a lipid 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| Snippet | Abstract Zn-alpha2-glycoprotein (ZAG) is a serum protein implicated in cancer cachexia and lipolysis. Our aim was to investigate serum levels of ZAG and... Zn-alpha2-glycoprotein (ZAG) is a serum protein implicated in cancer cachexia and lipolysis. Our aim was to investigate serum levels of ZAG and polymorphisms... |
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| SubjectTerms | Cachexia Endocrinology & Metabolism Female Genetic Association Studies Genotype Humans Immunoassay Lipids - blood Male Medical Genetics Medicin och hälsovetenskap Medicinsk genetik Polymorphism, Genetic Seminal Plasma Proteins - blood Seminal Plasma Proteins - genetics |
| Title | Preliminary report: Zn-alpha2-glycoprotein genotype and serum levels are associated with serum lipids |
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