Preliminary report: Zn-alpha2-glycoprotein genotype and serum levels are associated with serum lipids

• Published in: Metabolism, clinical and experimental Vol. 59; no. 9; pp. 1316 - 1318
• Main Authors: Olofsson, Louise E, Olsson, Bob, Lystig, Theodore, Jacobson, Peter, Jernås, Margareta, Sjöholm, Kajsa, Gummesson, Anders, Sjöström, Lars, Eriksson, Per, Hamsten, Anders, Hale, Laura P, Thelle, Dag S, Carlsson, Björn, Carlsson, Lena M.S
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2010
• Subjects: Cachexia; Endocrinology & Metabolism; Female; Genetic Association Studies; Genotype; Humans; Immunoassay; Lipids - blood; Male; Medical Genetics; Medicin och hälsovetenskap; Medicinsk genetik; Polymorphism, Genetic; Seminal Plasma Proteins - blood; Seminal Plasma Proteins - genetics
• ISSN: 0026-0495; 1532-8600; 1532-8600
• DOI: 10.1016/j.metabol.2009.12.006

Abstract Zn-alpha2-glycoprotein (ZAG) is a serum protein implicated in cancer cachexia and lipolysis. Our aim was to investigate serum levels of ZAG and polymorphisms in the ZAG gene in relation to serum lipids in man. Serum levels of ZAG correlated with serum levels of cholesterol ( P = .00088) in healthy subjects and during weight loss ( P = .059). The ZAG genotype was associated with total cholesterol ( P = .014) and low-density lipoprotein cholesterol ( P = .026) in healthy subjects, and the associations were replicated in an additional cohort ( P = .0017 and P = .060, respectively). Our data indicate that ZAG plays a role in lipid metabolism.