Anti-inflammatory effect of virgin olive oil in stable coronary disease patients: a randomized, crossover, controlled trial

• Published in: European journal of clinical nutrition Vol. 62; no. 4; pp. 570 - 574
• Main Authors: Fitó, M, Cladellas, M, Torre, R. de la, Marti, J, Munoz, D, Schroder, H, Alcantara, M, Pujadas-Bastardes, M, Marrugat, J, López-Sabater, M.C
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.04.2008; Nature Publishing; Nature Publishing Group
• Subjects: Adhesion; Aged; anti-inflammatory activity; Anti-inflammatory drugs; Antioxidants; Antioxidants - administration & dosage; Antioxidants - metabolism; Biological and medical sciences; C-reactive protein; C-Reactive Protein - metabolism; Cardiology; Cardiology. Vascular system; cardioprotective effect; Cardiovascular disease; Cardiovascular diseases; Clinical Nutrition; Coronary artery disease; Coronary Disease - blood; Coronary Disease - diet therapy; Coronary heart disease; Coronary vessels; Cross-Over Studies; Crossovers; Diet; Diet therapy; Dietary Fats, Unsaturated - administration & dosage; Dietary Fats, Unsaturated - metabolism; Disease control; Double-Blind Method; Drug therapy; Epidemiology; Feeding. Feeding behavior; Female; Fundamental and applied biological sciences. Psychology; Health aspects; Heart; Heart diseases; Humans; Inflammation; Interleukin 6; Interleukin-6 - blood; Interleukins; Internal Medicine; Lipid Metabolism - drug effects; Lipids; Male; Medical sciences; Medicine; Medicine & Public Health; Mediterranean diet; Metabolic Diseases; Nutrition; nutritional intervention; Olive Oil; Patients; Phenolic compounds; Phenols; Plant Oils - chemistry; Properties; Public Health; randomized clinical trials; short-communication; Vertebrates: anatomy and physiology, studies on body, several organs or systems; virgin olive oil; Spain; phenolic compounds; olive oil; coronary heart disease; inflammation; interleukins; Human; Nutrition; Interleukin; Cytokine; Antiinflammatory agent; Cardiovascular disease; Metabolic diseases; Inflammation; Olive oil; Coronary heart disease; Virgin oil; Randomization; Clinical trial
• ISSN: 0954-3007; 1476-5640
• DOI: 10.1038/sj.ejcn.1602724

Objectives: To assess the effect of two similar olive oils, but with differences in their phenolic compounds (powerful antioxidant compounds), on inflammatory markers in stable coronary heart disease patients. Design: Placebo-controlled, crossover, randomized trial. Setting: Cardiology Department of Hospital del Mar and Institut Municipal d'Investigació Mèdica (Barcelona). Subjects: Twenty-eight stable coronary heart disease patients. Interventions: A raw daily dose of 50 ml of virgin and refined olive oil (ROO) was sequentially administered over two periods of 3-weeks, preceded by 2-week washout periods in which ROO was used. Results: Interleukin-6 (P<0.002) and C-reactive protein (P=0.024) decreased after virgin olive oil intervention. No changes were observed in soluble intercellular and vascular adhesion molecules, glucose and lipid profile. Conclusions: Consumption of virgin olive oil, could provide beneficial effects in stable coronary heart disease patients as an additional intervention to the pharmacological treatment.