An essential role for PNLDC1 in piRNA 3＇ end trimming and male fertility in mice

Dear Editor, PIWI-interacting RNAs （piRNAs） are germ cell-specific small non-coding RNAs that are essential for silenc- ing transposable elements. Substantial efforts in the past decade have led to an understanding of how piRNAs are made. Primary piRNA biogenesis is initiated with transcription of p...

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Published inCell research Vol. 27; no. 11; pp. 1392 - 1396
Main Authors Zhang, Yue, Guo, Rui, Cui, Yiqiang, Zhu, Zhiping, Zhang, Yingwen, Wu, Hao, Zheng, Bo, Yue, Qiuling, Bai, Shun, Zeng, Wentao, Guo, Xuejiang, Zhou, Zuomin, Shen, Bin, Zheng, Ke, Liu, Mingxi, Ye, Lan, Sha, Jiahao
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.11.2017
Nature Publishing Group
Subjects
631/136/2434/1822
631/443/494
631/45/500
631/80/641/1633
Animals
Biomedical and Life Sciences
Cell Biology
Female
Fertility
Fertility - genetics
Letter to the Editor
Life Sciences
Male
Mice
Mice, Knockout
Ribonucleases - genetics
Ribonucleases - physiology
RNA, Small Interfering - metabolism
Spermatogenesis - genetics
Testis - metabolism
Online AccessGet full text
ISSN1001-0602
1748-7838
1748-7838
DOI10.1038/cr.2017.125

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Summary:Dear Editor, PIWI-interacting RNAs （piRNAs） are germ cell-specific small non-coding RNAs that are essential for silenc- ing transposable elements. Substantial efforts in the past decade have led to an understanding of how piRNAs are made. Primary piRNA biogenesis is initiated with transcription of piRNA precursors, followed by cleavage into piRNA intermediates, and finally, maturation by 3＇ end trimming and 2＇-O-methylation. Secondary piRNA biogenesis occurs through an amplification loop （ping pong pathway）; the piRNA pools generated through pri- mary processing guide MILI protein to cleave the target RNA for piRNA generation in a feed-forward loop that accelerates production of the piRNAs. Papi/Tdrkh has been implicated in processing the 3＇ ends of piRNAs [1, 2], however,
Bibliography:31-1568
Dear Editor, PIWI-interacting RNAs （piRNAs） are germ cell-specific small non-coding RNAs that are essential for silenc- ing transposable elements. Substantial efforts in the past decade have led to an understanding of how piRNAs are made. Primary piRNA biogenesis is initiated with transcription of piRNA precursors, followed by cleavage into piRNA intermediates, and finally, maturation by 3＇ end trimming and 2＇-O-methylation. Secondary piRNA biogenesis occurs through an amplification loop （ping pong pathway）; the piRNA pools generated through pri- mary processing guide MILI protein to cleave the target RNA for piRNA generation in a feed-forward loop that accelerates production of the piRNAs. Papi/Tdrkh has been implicated in processing the 3＇ ends of piRNAs [1, 2], however
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These four authors contributed equally to this work.
ISSN:1001-0602
1748-7838
1748-7838
DOI:10.1038/cr.2017.125