Deficient Adolescent Social Behavior Following Early-Life Inflammation is Ameliorated by Augmentation of Anandamide Signaling

Highlights • Early-life inflammation on P14 decreases social behavior in adolescent rats. • LPS leads to an acute increase in anandamide (AEA) 6h after LPS injection on P14. • P14 LPS reduces CB1 binding and alters FAAH activity and AEA in adolescent animals. • FAAH inhibitor PF-04457845 (orally or...

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Published inBrain, behavior, and immunity Vol. 58; pp. 237 - 247
Main Authors Doenni, V.M, Gray, J.M, Song, C.M, Patel, S, Hill, M.N, Pittman, Q.J
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Inc 01.11.2016
Subjects
Allergy and Immunology
Amidohydrolases - antagonists & inhibitors
Amidohydrolases - metabolism
Amygdala
Amygdala - metabolism
Animals
Anxiety
Arachidonic Acids - metabolism
Autism
Behavior, Animal
Early-life inflammation
Endocannabinoid
Endocannabinoids - metabolism
FAAH
Female
Glycerides - metabolism
Inflammation - chemically induced
Inflammation - psychology
Lipopolysaccharides
LPS
Male
Polyunsaturated Alkamides - metabolism
Psychiatry
Pyridazines - administration & dosage
Rats, Sprague-Dawley
Receptor, Cannabinoid, CB1 - metabolism
Signal Transduction
Social Behavior
Urea - administration & dosage
Urea - analogs & derivatives
Autism
FAAH
Social behavior
Endocannabinoid
Amygdala
Early-life inflammation
Anxiety
LPS
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Summary:Highlights • Early-life inflammation on P14 decreases social behavior in adolescent rats. • LPS leads to an acute increase in anandamide (AEA) 6h after LPS injection on P14. • P14 LPS reduces CB1 binding and alters FAAH activity and AEA in adolescent animals. • FAAH inhibitor PF-04457845 (orally or in the amygdala) rescues social behavior.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Vienna M Doenni, VDOENNI@UCALGARY.CA
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2016.07.152