Impact of Transferrin Saturation and Anemia on Radial Artery Calcification in Patients with End-Stage Kidney Disease

• Published in: Nutrients Vol. 14; no. 20; p. 4269
• Main Authors: Kano, Toshiki, Io, Hiroaki, Nakata, Junichiro, Sasaki, Yu, Muto, Masahiro, Shimizu, Yuki, Fukao, Yusuke, Fukuzaki, Haruna, Maeda, Takuya, Hosoya, Reina, Suzuki, Yusuke
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.10.2022; MDPI
• Subjects: Anemia; Anemia - etiology; Aorta; Arteriosclerosis; arteriovenous fistula; Blood pressure; Calcification; Calcification (ectopic); Calcinosis; Cholesterol; Chronic kidney failure; Cohort Studies; Creatinine; Diabetes; end-stage kidney disease; End-stage renal disease; Fistula; Hemodialysis; Hemoglobin; Hemoglobins; High density lipoprotein; Hospitals; Humans; Iron; Kidney diseases; Kidney Failure, Chronic - complications; Kidney Failure, Chronic - therapy; Kidneys; Laboratories; Medical research; Medicine, Experimental; Mortality; Multivariate analysis; Oxidative stress; Patients; Phosphatase; Phosphorus; Prognosis; Radial Artery; radial artery calcification; Regression analysis; Renal Dialysis; Risk analysis; Risk Factors; Saturation; Surgery; Transferrin; Transferrins; Value-added tax; Vascular Calcification; Veins & arteries; Japan; arteriovenous fistula; radial artery calcification; end-stage kidney disease
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu14204269

Background: Arterial calcification is an important factor in determining the prognosis of patients with chronic kidney disease (CKD). Few studies on aortic calcification have involved radial artery calcification (RAC). This study aimed to analyze risk factors for RAC in patients with end-stage kidney disease (ESKD) and investigate the relationship between subsequent cardiovascular events (CVE) and vascular access trouble (VAT). Methods: This cohort study included 64 consecutive patients with ESKD who initiated hemodialysis and underwent a procedure for the creation of a primary radiocephalic arteriovenous fistula (RCAVF). Small arterial specimens were obtained from patients during RCAVF surgery. Tissue samples were stained with von Kossa, and arterial microcalcification was evaluated. We analyzed the association between preexisting arterial microcalcifications, clinical characteristics, CVE, and VAT. Results: In the univariate analysis, RAC patients demonstrated high systolic blood pressure (sBP), low hemoglobin (Hb), and low transferrin saturation (TSAT) (<0.05, <0.05, and <0.05, respectively). In the multivariate analysis, Hb (HR−0.516 (0.278−0.959), p < 0.05), TSAT (HR−0.0012 (0.00000248−0.597), p < 0.05), and sBP (HR−1.037 (1.001−1.073), p < 0.05) were independent risk factors for RAC. The cumulative incidence rate of CVE/VAT was not associated with RAC for one year. Conclusion: RAC was associated with sBP, TSAT, and anemia; however, no association with CVE/VAT was observed.