Increased cyclin T1 expression as a favorable prognostic factor in treating gastric adenocarcinoma

• Published in: Oncology letters Vol. 10; no. 6; pp. 3712 - 3718
• Main Authors: JIN, JONG-SHIAW, LIN, LIEN-FU, CHEN, JUI-CHANG, HUANG, CHIA-CHI, SHEU, JENG-HORNG, CHEN, WENLUNG, TSAO, TANG-YI, HSU, CHIH-WEI
• Format: Journal Article
• Language: English
• Published: Greece D.A. Spandidos 01.12.2015; Spandidos Publications; Spandidos Publications UK Ltd
• Subjects: Adenocarcinoma; Antigens; Cancer therapies; Cell cycle; cyclin T1; cyclin-dependent kinase 9; Cyclin-dependent kinases; Cyclins; disease-free survival; gastric adenocarcinoma; Gastric cancer; Gene expression; Genetic aspects; Health aspects; HIV; Human immunodeficiency virus; Kinases; Medical prognosis; Metastasis; Oncology; Phosphorylation; Prognosis; RNA polymerase; Stomach cancer; cyclin T1; gastric adenocarcinoma; disease-free survival; cyclin-dependent kinase 9
• ISSN: 1792-1074; 1792-1082
• DOI: 10.3892/ol.2015.3749

The expression of cyclin A, B1, D1 and E in gastric adenocarcinoma is known to be associated with clinical outcome. However, few studies have investigated the role of cyclin T1 and cyclin-dependent kinase 9 (CDK9) in gastric adenocarcinoma. Therefore, this study assessed the clinical significance of cyclin T1 and CDK9 expression in gastric adenocarcinoma. A total of 39 gastric adenocarcinoma patients received either radical total or distal gastrectomy in this study. Surgical tissue slides were stained with CDK9 and cyclin T1 antibodies, and immunohistochemistry scores and disease-free survival (DFS) rates were analyzed. Among the 19 patients with tumor-recurrent or distant metastasis, 16 were recorded as exhibiting low expression of cyclin T1. The remaining three patients exhibited high expression of the antibody. The results of patients with a higher T stage, N stage and tumor grade were less favorable. For patients with adenocarcinoma, the percentage of tissue slides stained with cyclin T1 was significantly higher than for those with normal stomach epithelia. The DFS rates of patients with low expression of cyclin T1 were significantly associated with poorer DFS rates. In conclusion, high expression of cyclin T1 is a favorable prognostic factor in treating patients with stomach adenocarcinoma.