Tools of the trade: psychophysiological interactions and functional connectivity

Psychophysiological interactions (PPIs) analysis is a method for investigating task-specific changes in the relationship between activity in different brain areas, using functional magnetic resonance imaging (fMRI) data. Specifically, PPI analyses identify voxels in which activity is more related to...

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Bibliographic Details
Published inSocial cognitive and affective neuroscience Vol. 7; no. 5; pp. 604 - 609
Main Authors O’Reilly, Jill X., Woolrich, Mark W., Behrens, Timothy E.J., Smith, Stephen M., Johansen-Berg, Heidi
Format Journal Article
LanguageEnglish
Published England Oxford University Press 01.06.2012
Subjects
Brain - blood supply
Brain - physiology
Brain Mapping
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Neural Pathways - blood supply
Neural Pathways - physiology
Original
Oxygen - blood
Psychophysiology
Task Performance and Analysis
PPI
resting state
psychophysiological interactions
functional connectivity
Online AccessGet full text
ISSN1749-5016
1749-5024
1749-5024
DOI10.1093/scan/nss055

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Summary:Psychophysiological interactions (PPIs) analysis is a method for investigating task-specific changes in the relationship between activity in different brain areas, using functional magnetic resonance imaging (fMRI) data. Specifically, PPI analyses identify voxels in which activity is more related to activity in a seed region of interest (seed ROI) in a given psychological context, such as during attention or in the presence of emotive stimuli. In this tutorial, we aim to give a simple conceptual explanation of how PPI analysis works, in order to assist readers in planning and interpreting their own PPI experiments.
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ISSN:1749-5016
1749-5024
1749-5024
DOI:10.1093/scan/nss055