Acquired cutis laxa associated with inflammatory bowel disease, inflammatory arthritis and IgA nephropathy

Skin biopsy under hematoxylin and eosin staining showed mild increase in collagen and marked reduction in elastin fibers under orcein stain with fragmentation and elastolysis of elastin in the mid and deep dermis suggestive of cutis laxa [Figure 2]. Generalized acquired cutis laxa can be idiopathic...

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Published inIndian journal of dermatology, venereology, and leprology Vol. 84; no. 6; p. 763
Main Authors Nirmal, Balakrishnan, George, Renu, Bindra, Mandeep
Format Journal Article
LanguageEnglish
Published India Wolters Kluwer India Pvt. Ltd 01.11.2018
Medknow Publications and Media Pvt. Ltd
Scientific Scholar
Subjects
Abdomen
Adult
Arthritis
Arthritis - complications
Arthritis - diagnosis
Crohns disease
Cutis Laxa - diagnosis
Cutis Laxa - etiology
Emphysema
Female
Glomerulonephritis, IGA - complications
Glomerulonephritis, IGA - diagnosis
Humans
Inflammatory Bowel Diseases - complications
Inflammatory Bowel Diseases - diagnosis
Mutation
Plastic surgery
Proteins
Tuberculosis
Urine
Bangladesh
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Summary:Skin biopsy under hematoxylin and eosin staining showed mild increase in collagen and marked reduction in elastin fibers under orcein stain with fragmentation and elastolysis of elastin in the mid and deep dermis suggestive of cutis laxa [Figure 2]. Generalized acquired cutis laxa can be idiopathic or associated with infections, drugs, sarcoidosis, amyloidosis, systemic lupus erythematosus, glomerulonephritis, mesangial IgA nephropathy, paraproteinemia, multiple myeloma and Hodgkin's disease. [4] Our patient with generalized cutis laxa was associated with IgA nephropathy, Crohn's disease, and inflammatory polyarthritis suggesting that elastic tissue destruction may be an immune-mediated mechanism, as seen with these autoimmune disorders.
ISSN:0378-6323
0973-3922
1998-3611
DOI:10.4103/ijdvl.IJDVL_904_16