Aggressive behavior in humans: Genes and pathways identified through association studies
Aggressive behavior has both genetic and environmental components. Many association studies have been performed to identify genetic factors underlying aggressive behaviors in humans. In this review we summarize the previous work performed in this field, considering both candidate gene (CGAS) and gen...
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Published in | American journal of medical genetics. Part B, Neuropsychiatric genetics Vol. 171B; no. 5; pp. 676 - 696 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
United States
Blackwell Publishing Ltd
01.07.2016
Wiley Subscription Services, Inc |
Subjects | |
Online Access | Get full text |
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Summary: | Aggressive behavior has both genetic and environmental components. Many association studies have been performed to identify genetic factors underlying aggressive behaviors in humans. In this review we summarize the previous work performed in this field, considering both candidate gene (CGAS) and genome‐wide association studies (GWAS), excluding those performed in samples where the primary diagnosis is a psychiatric or neurological disorder other than an aggression‐related phenotype. Subsequently, we have studied the enrichment of pathways and functions in GWAS data. The results of our searches show that most CGAS have identified associations with genes involved in dopaminergic and serotonergic neurotransmission and in hormone regulation. On the other hand, GWAS have not yet identified genome‐wide significant associations, but top nominal findings are related to several signaling pathways, such as axon guidance or estrogen receptor signaling, and also to neurodevelopmental processes and synaptic plasticity. Future studies should use larger samples, homogeneous phenotypes and standardized measurements to identify genes that underlie aggressive behaviors in humans. © 2016 Wiley Periodicals, Inc. |
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Bibliography: | Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER) Spanish "Ministerio de Economía y Competitividad" - No. SAF2012-33484 European Community's Seventh Framework Programme - No. 602805 istex:927084B25A7D50F06793D97FBD6332D43946903A ArticleID:AJMGB32419 AGAUR - No. 2014SGR932 ark:/67375/WNG-7W021KLC-N ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 ObjectType-Article-1 ObjectType-Feature-2 |
ISSN: | 1552-4841 1552-485X |
DOI: | 10.1002/ajmg.b.32419 |