Phosphatase-Triggered Fusogenic Liposomes for Cytoplasmic Delivery of Cell-Impermeable Compounds
License to fuse! A phosphorylated fusion peptide can mediate membrane fusion when the phosphates (green triangles, see scheme) are removed by phosphatases (blue spheres), delivering the contents of the liposome into the cytosol. This phosphatase‐triggered approach may be useful to create target‐spec...
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Published in | Angewandte Chemie (International ed.) Vol. 51; no. 36; pp. 9047 - 9051 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Weinheim
WILEY-VCH Verlag
03.09.2012
WILEY‐VCH Verlag Wiley Subscription Services, Inc |
Edition | International ed. in English |
Subjects | |
Online Access | Get full text |
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Summary: | License to fuse! A phosphorylated fusion peptide can mediate membrane fusion when the phosphates (green triangles, see scheme) are removed by phosphatases (blue spheres), delivering the contents of the liposome into the cytosol. This phosphatase‐triggered approach may be useful to create target‐specific lipid nanocarriers. |
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Bibliography: | ark:/67375/WNG-VVRVV8W1-V Deutsche Forschungsgemeinschaft DFG istex:B6AA62A0C4C631F8F4DAC20A62C6A7A9B20ADD9F This work was supported by the National Institute of Health (R01GM003008). J.P.M.M. is a recipient of the NIGMS predoctoral fellowship, supported by the NIGMS-IMSD grant (R25-GM56847). J.N. is supported by the Deutsche Forschungsgemeinschaft Fellowship (DFG). We thank Dr. Justin Chan and Dr. David Pham for their assistance with peptide synthesis and Sebastian Peck and Jessica Wong from the Biological Imaging Development Center at UCSF for their assistance in confocal microscopy. National Institute of Health - No. R01GM003008 ArticleID:ANIE201204198 NIGMS-IMSD - No. R25-GM56847 This work was supported by the National Institute of Health (R01GM003008). J.P.M.M. is a recipient of the NIGMS predoctoral fellowship, supported by the NIGMS‐IMSD grant (R25‐GM56847). J.N. is supported by the Deutsche Forschungsgemeinschaft Fellowship (DFG). We thank Dr. Justin Chan and Dr. David Pham for their assistance with peptide synthesis and Sebastian Peck and Jessica Wong from the Biological Imaging Development Center at UCSF for their assistance in confocal microscopy. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1433-7851 1521-3773 |
DOI: | 10.1002/anie.201204198 |