Marine Pyridoacridine Alkaloids: Biosynthesis and Biological Activities

Pyridoacridines are a class of strictly marine‐derived alkaloids that constitute one of the largest chemical families of marine alkaloids. During the last few years, both natural pyridoacridines and their analogues have constituted excellent targets for synthetic works. They have been the subject of...

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Published inChemistry & biodiversity Vol. 13; no. 1; pp. 37 - 47
Main Authors Ibrahim, Sabrin R. M., Mohamed, Gamal A.
Format Journal Article
LanguageEnglish
Published Zürich WILEY-VCH Verlag 01.01.2016
WILEY‐VCH Verlag
Wiley Subscription Services, Inc
Subjects
Acridines - chemistry
Acridines - metabolism
Acridines - pharmacology
Alkaloids
Alkaloids - biosynthesis
Alkaloids - chemistry
Alkaloids - pharmacology
Animals
Anti-HIV Agents - chemistry
Anti-HIV Agents - metabolism
Anti-HIV Agents - pharmacology
Anti-Infective Agents - chemistry
Anti-Infective Agents - metabolism
Anti-Infective Agents - pharmacology
Antineoplastic Agents - chemistry
Antineoplastic Agents - metabolism
Antineoplastic Agents - pharmacology
Antiparasitic Agents - chemistry
Antiparasitic Agents - metabolism
Antiparasitic Agents - pharmacology
Ascidians
Biological activity
Biosynthesis
Cell Proliferation - drug effects
Human immunodeficiency virus
Humans
Insecticides - chemistry
Insecticides - metabolism
Insecticides - pharmacology
Molecular Structure
Phenanthrolines - chemistry
Phenanthrolines - metabolism
Phenanthrolines - pharmacology
Pyridoacridine
Review
Reviews
Alkaloids
Biosynthesis
Pyridoacridine
Ascidians
Biological activity
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Summary:Pyridoacridines are a class of strictly marine‐derived alkaloids that constitute one of the largest chemical families of marine alkaloids. During the last few years, both natural pyridoacridines and their analogues have constituted excellent targets for synthetic works. They have been the subject of intense study due to their significant biological activities; cytotoxic, antibacterial, antifungal, antiviral, insecticidal, anti‐HIV, and anti‐parasitic activities. In the present review, 95 pyridoacridine alkaloids isolated from marine organisms are discussed in term of their occurrence, biosynthesis, biological activities, and structural assignment.
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ISSN:1612-1872
1612-1880
DOI:10.1002/cbdv.201400434