Regulation of neuronal development and function by ROS

• Published in: FEBS letters Vol. 592; no. 5; pp. 679 - 691
• Main Authors: Oswald, Matthew C. W., Garnham, Nathan, Sweeney, Sean T., Landgraf, Matthias
• Format: Journal Article
• Language: English
• Published: England John Wiley and Sons Inc 01.03.2018
• Subjects: Aging - genetics; Aging - metabolism; Aging - pathology; Animals; axon; cytoskeleton; dendrite; Growth Cones - metabolism; Growth Cones - pathology; Humans; metabolism; NADPH oxidase; Nerve Net - metabolism; Nerve Net - pathology; nervous system; Neurodegenerative Diseases - genetics; Neurodegenerative Diseases - metabolism; Neurodegenerative Diseases - pathology; Neurogenesis; neuronal polarity; neurons; pathfinding; plasticity; reactive oxygen species; Reactive Oxygen Species - metabolism; Review; synapse; Synaptic Transmission; pathfinding; nervous system; cytoskeleton; NADPH oxidase; reactive oxygen species; neuronal polarity; dendrite; plasticity; axon; synapse
• ISSN: 0014-5793; 1873-3468; 1873-3468
• DOI: 10.1002/1873-3468.12972

Reactive oxygen species (ROS) have long been studied as destructive agents in the context of nervous system ageing, disease and degeneration. Their roles as signalling molecules under normal physiological conditions is less well understood. Recent studies have provided ample evidence of ROS‐regulating neuronal development and function, from the establishment of neuronal polarity to growth cone pathfinding; from the regulation of connectivity and synaptic transmission to the tuning of neuronal networks. Appreciation of the varied processes that are subject to regulation by ROS might help us understand how changes in ROS metabolism and buffering could progressively impact on neuronal networks with age and disease.