Isomalabaricane Triterpenes from the Marine Sponge Rhabdastrella sp

The marine sponge of the genus , , , and are characterized chemically by a variety of isomalabaricane triterpenes. This class of compounds drew spotlights in marine lead discovery due to their profound anti-proliferative properties. Further research on exploring its chemical diversity led to the ide...

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Bibliographic Details
Published inMarine drugs Vol. 19; no. 4; p. 206
Main Authors Lai, Kuei-Hung, Huang, Zheng-Hao, El-Shazly, Mohamed, Peng, Bo-Rong, Wei, Wen-Chi, Su, Jui-Hsin
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 06.04.2021
MDPI
Subjects
anti-leukemia
Cancer
Carbon
Chromatography
Cytotoxicity
isomalabaricane
Leukemia
Marine invertebrates
Metabolites
Rhabdastrella
Spectrum analysis
Tetrahydrofuran
tetrahydrofuran moiety
Triterpenes
Japan
Germany
tetrahydrofuran moiety
isomalabaricane
anti-leukemia
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Summary:The marine sponge of the genus , , , and are characterized chemically by a variety of isomalabaricane triterpenes. This class of compounds drew spotlights in marine lead discovery due to their profound anti-proliferative properties. Further research on exploring its chemical diversity led to the identifications of two new isomalabaricane-type triterpenes rhabdastin H ( ) and rhabdastin I ( ). Their structures were unraveled using a series of spectroscopic approaches. These isolates were found to exhibit unique structural features with the only reported tetrahydrofuran functionality among all marine-derived isomalabaricanes. Both compounds and showed activities against K562 (IC 11.7 and 9.8 μM) and Molt4 (IC 16.5 and 11.0 μM) leukemic cells in MTT cell proliferative assay.
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ISSN:1660-3397
1660-3397
DOI:10.3390/md19040206