Differences In High-Intensity Signal Volume Between Arterial Spin Labeling And Contrast-Enhanced T1-Weighted Imaging May Be Useful For Differentiating Glioblastoma From Brain Metastasis

Purpose: To determine whether differences in tumor volume between arterial spin labeling (ASL) and contrast-enhanced T1-weighted MR images (CE+T1WI) can help differentiate glioblastoma (GBM) from brain metastasis. Materials and methods: Patients with a diagnosis of GBM (n=25) or brain metastasis (n=...

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Published inThe Journal of Medical Investigation Vol. 64; no. 1.2; pp. 58 - 63
Main Authors MD, Mungunbagana Ganbold, PhD, Masafumi Harada, MD, PhD, Delgerdalai Khashbat, MD, PhD, Takashi Abe, MD, PhD, Teruyoshi Kageji, MD, PhD, Shinji Nagahiro, MD
Format Journal Article
LanguageEnglish
Published Japan The University of Tokushima Faculty of Medicine 2017
Subjects
Adult
Aged
Aged, 80 and over
arterial spin labeling
Brain Neoplasms - diagnosis
Brain Neoplasms - diagnostic imaging
Brain Neoplasms - secondary
Diagnosis, Differential
Female
glioblastoma
Glioblastoma - diagnosis
Glioblastoma - diagnostic imaging
Humans
Magnetic Resonance Angiography - methods
Male
metastasis
Middle Aged
perfusion
Prospective Studies
Spin Labels
volumetric analysis
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Summary:Purpose: To determine whether differences in tumor volume between arterial spin labeling (ASL) and contrast-enhanced T1-weighted MR images (CE+T1WI) can help differentiate glioblastoma (GBM) from brain metastasis. Materials and methods: Patients with a diagnosis of GBM (n=25) or brain metastasis (n=13) were examined by both conventional and ASL MR imaging. Volumes of interest with high signal intensity on ASL and CE+T1WI were defined using three dimensional analysis software. Tumor volume difference (ASL-CE) and tumor volume ratio (ASL/CE) were obtained. Absolute maximal tumor blood flow (TBF) and TBF ratio (normalized to white matter) were also measured. The Mann-Whitney U test and receiver operating characteristic curve analysis were performed to compare measurements between the tumor groups. Results: Both tumor volume difference and tumor volume ratio were significantly higher in GBM than in metastasis. Both TBF and TBF ratio were higher for GBM than for metastasis, but the differences were not significant. Conclusion: The difference in tumor volume as measured by ASL high signal intensity and CE+T1WI might be useful for differentiating GBM from metastasis, whereas ASL-derived TBF is insufficient. J. Med. Invest. 64: 58-63, February, 2017
ISSN:1343-1420
1349-6867
DOI:10.2152/jmi.64.58