Psychotropic Drugs for the Management of Chronic Pain and Itch

Clinical observations have shown that patients with chronic neuropathic pain or itch exhibit symptoms of increased anxiety, depression and cognitive impairment. Such patients need corrective therapy with antidepressants, antipsychotics or anticonvulsants. It is known that some psychotropic drugs are...

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Published inPharmaceuticals (Basel, Switzerland) Vol. 12; no. 2; p. 99
Main Authors Belinskaia, Daria A, Belinskaia, Mariia A, Barygin, Oleg I, Vanchakova, Nina P, Shestakova, Natalia N
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 24.06.2019
MDPI
Subjects
Analgesics
animal model
Anticonvulsants
Antidepressants
Chronic pain
clinical trial
Diabetic neuropathy
Drugs
Mental depression
Mental disorders
Narcotics
Nervous system
Pain management
pharmacological profile
Pruritus
Psychotropic drugs
Restless legs syndrome
Review
Serotonin
Sodium
clinical trial
chronic pain
animal model
psychotropic drugs
pharmacological profile
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Summary:Clinical observations have shown that patients with chronic neuropathic pain or itch exhibit symptoms of increased anxiety, depression and cognitive impairment. Such patients need corrective therapy with antidepressants, antipsychotics or anticonvulsants. It is known that some psychotropic drugs are also effective for the treatment of neuropathic pain and pruritus syndromes due to interaction with the secondary molecular targets. Our own clinical studies have identified antipruritic and/or analgesic efficacy of the following compounds: tianeptine (atypical tricyclic antidepressant), citalopram (selective serotonin reuptake inhibitor), mianserin (tetracyclic antidepressant), carbamazepine (anticonvulsant), trazodone (serotonin antagonist and reuptake inhibitor), and chlorprothixene (antipsychotic). Venlafaxine (serotonin-norepinephrine reuptake inhibitor) is known to have an analgesic effect too. The mechanism of such effect of these drugs is not fully understood. Herein we review and correlate the literature data on analgesic/antipruritic activity with pharmacological profile of these compounds.
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These authors contributed equally to this work.
ISSN:1424-8247
1424-8247
DOI:10.3390/ph12020099