Lipocalin-type prostaglandin D synthase is a powerful biomarker for severity of stable coronary artery disease

• Published in: Atherosclerosis Vol. 201; no. 2; pp. 385 - 391
• Main Authors: Inoue, Teruo, Eguchi, Yutaka, Matsumoto, Tetsuya, Kijima, Yoshiyuki, Kato, Yoji, Ozaki, Yukio, Waseda, Katsuhisa, Oda, Hiroshi, Seiki, Kosuke, Node, Koichi, Urade, Yoshihiro
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ireland Ltd 01.12.2008; Elsevier
• Subjects: Aged; Atherosclerosis; Atherosclerosis (general aspects, experimental research); Atherosclerosis - metabolism; Biological and medical sciences; Biomarker; Biomarkers - blood; Blood and lymphatic vessels; Cardiology. Vascular system; Cardiovascular; Coronary artery disease; Coronary Artery Disease - metabolism; Coronary heart disease; Enzyme-Linked Immunosorbent Assay; Female; Heart; Humans; Intramolecular Oxidoreductases - blood; Lipocalin-type prostaglandin D synthase; Lipocalins - blood; Lipocalins - metabolism; Male; Medical sciences; Middle Aged; Prostaglandin D 2; Prostaglandin D2 - metabolism; Regression Analysis; Risk Factors; ROC Curve; Biomarker; Prostaglandin D 2; Lipocalin-type prostaglandin D synthase; Coronary artery disease; Atherosclerosis; Vascular disease; Prostaglandin; Arachidonic acid derivatives; Eicosanoid; Cardiovascular disease; Prostaglandin D2; Coronary heart disease
• ISSN: 0021-9150; 1879-1484
• DOI: 10.1016/j.atherosclerosis.2008.03.010

Abstract Lipocalin-type prostaglandin D synthase (L-PGDS), which is responsible for the biosynthesis of prostaglandin (PG) D2 , has been found to be present in the atherosclerotic plaque of the human coronary artery and also to be detectable in human serum. This multicenter cooperative study was designed to establish the diagnostic value of measuring serum L-PGDS for coronary artery disease. The study included 1013 consecutive patients suspected of having stable coronary artery disease who underwent diagnostic coronary angiography. Peripheral blood was collected prior to angiography. The serum level of L-PGDS, as determined by a sandwich ELISA, was 58.1 ± 2.2, 62.0 ± 1.8 and 80.6 ± 2.6 μg/dl for patients with no stenotic lesion (N, n = 241), single-vessel coronary artery disease (S, n = 351), and multi-vessel coronary artery disease (M, n = 421), respectively (N vs. S; P < 0.001, S vs. M; P < 0.01, N vs. M; P < 0.001). Multiple regression analysis indicated that the most powerful independent predictor of the coronary severity score (Gensini Score) was the L-PGDS level ( R = 0.55, P < 0.0001). The serum L-PGDS level is suitable to evaluate the severity of coronary artery disease. The measurement of serum L-PGDS can be a strategy for screening of stable coronary artery disease prior to coronary angiography.