Drug Discovery Based on Fluorine-Containing Glycomimetics

• Published in: Molecules (Basel, Switzerland) Vol. 28; no. 18; p. 6641
• Main Authors: Wei, Xingxing, Wang, Pengyu, Liu, Fen, Ye, Xinshan, Xiong, Decai
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.09.2023; MDPI
• Subjects: Carbohydrates; Cell differentiation; Drug discovery; Fluorides; fluorination; Fluorine; Fluorine compounds; glycomimetics; Metastasis; NMR; Nuclear magnetic resonance; Pharmacokinetics; physical properties; Polysaccharides; Protein binding; Proteins; Reagents; Review; Sugar; synthesis

Glycomimetics, which are synthetic molecules designed to mimic the structures and functions of natural carbohydrates, have been developed to overcome the limitations associated with natural carbohydrates. The fluorination of carbohydrates has emerged as a promising solution to dramatically enhance t...