Drug Discovery Based on Fluorine-Containing Glycomimetics

Glycomimetics, which are synthetic molecules designed to mimic the structures and functions of natural carbohydrates, have been developed to overcome the limitations associated with natural carbohydrates. The fluorination of carbohydrates has emerged as a promising solution to dramatically enhance t...

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Published inMolecules (Basel, Switzerland) Vol. 28; no. 18; p. 6641
Main Authors Wei, Xingxing, Wang, Pengyu, Liu, Fen, Ye, Xinshan, Xiong, Decai
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.09.2023
MDPI
Subjects
Carbohydrates
Cell differentiation
Drug discovery
Fluorides
fluorination
Fluorine
Fluorine compounds
glycomimetics
Metastasis
NMR
Nuclear magnetic resonance
Pharmacokinetics
physical properties
Polysaccharides
Protein binding
Proteins
Reagents
Review
Sugar
synthesis
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Summary:Glycomimetics, which are synthetic molecules designed to mimic the structures and functions of natural carbohydrates, have been developed to overcome the limitations associated with natural carbohydrates. The fluorination of carbohydrates has emerged as a promising solution to dramatically enhance the metabolic stability, bioavailability, and protein-binding affinity of natural carbohydrates. In this review, the fluorination methods used to prepare the fluorinated carbohydrates, the effects of fluorination on the physical, chemical, and biological characteristics of natural sugars, and the biological activities of fluorinated sugars are presented.
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These authors contributed equally to this work.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules28186641