Drug Discovery Based on Fluorine-Containing Glycomimetics

Glycomimetics, which are synthetic molecules designed to mimic the structures and functions of natural carbohydrates, have been developed to overcome the limitations associated with natural carbohydrates. The fluorination of carbohydrates has emerged as a promising solution to dramatically enhance t...

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Published inMolecules (Basel, Switzerland) Vol. 28; no. 18; p. 6641
Main Authors Wei, Xingxing, Wang, Pengyu, Liu, Fen, Ye, Xinshan, Xiong, Decai
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.09.2023
MDPI
Subjects
Carbohydrates
Cell differentiation
Drug discovery
Fluorides
fluorination
Fluorine
Fluorine compounds
glycomimetics
Metastasis
NMR
Nuclear magnetic resonance
Pharmacokinetics
physical properties
Polysaccharides
Protein binding
Proteins
Reagents
Review
Sugar
synthesis
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Abstract Glycomimetics, which are synthetic molecules designed to mimic the structures and functions of natural carbohydrates, have been developed to overcome the limitations associated with natural carbohydrates. The fluorination of carbohydrates has emerged as a promising solution to dramatically enhance the metabolic stability, bioavailability, and protein-binding affinity of natural carbohydrates. In this review, the fluorination methods used to prepare the fluorinated carbohydrates, the effects of fluorination on the physical, chemical, and biological characteristics of natural sugars, and the biological activities of fluorinated sugars are presented.
AbstractList Glycomimetics, which are synthetic molecules designed to mimic the structures and functions of natural carbohydrates, have been developed to overcome the limitations associated with natural carbohydrates. The fluorination of carbohydrates has emerged as a promising solution to dramatically enhance the metabolic stability, bioavailability, and protein-binding affinity of natural carbohydrates. In this review, the fluorination methods used to prepare the fluorinated carbohydrates, the effects of fluorination on the physical, chemical, and biological characteristics of natural sugars, and the biological activities of fluorinated sugars are presented.
Glycomimetics, which are synthetic molecules designed to mimic the structures and functions of natural carbohydrates, have been developed to overcome the limitations associated with natural carbohydrates. The fluorination of carbohydrates has emerged as a promising solution to dramatically enhance the metabolic stability, bioavailability, and protein-binding affinity of natural carbohydrates. In this review, the fluorination methods used to prepare the fluorinated carbohydrates, the effects of fluorination on the physical, chemical, and biological characteristics of natural sugars, and the biological activities of fluorinated sugars are presented.Glycomimetics, which are synthetic molecules designed to mimic the structures and functions of natural carbohydrates, have been developed to overcome the limitations associated with natural carbohydrates. The fluorination of carbohydrates has emerged as a promising solution to dramatically enhance the metabolic stability, bioavailability, and protein-binding affinity of natural carbohydrates. In this review, the fluorination methods used to prepare the fluorinated carbohydrates, the effects of fluorination on the physical, chemical, and biological characteristics of natural sugars, and the biological activities of fluorinated sugars are presented.
Audience Academic
Author Liu, Fen
Wei, Xingxing
Ye, Xinshan
Wang, Pengyu
Xiong, Decai
AuthorAffiliation 2 State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Rd. No. 38, Beijing 100191, China liufen@bjmu.edu.cn (F.L.); xinshan@bjmu.edu.cn (X.Y.)
1 Department of Pharmacy, Changzhi Medical College, No. 161, Jiefang East Street, Changzhi 046012, China
AuthorAffiliation_xml – name: 1 Department of Pharmacy, Changzhi Medical College, No. 161, Jiefang East Street, Changzhi 046012, China
– name: 2 State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Rd. No. 38, Beijing 100191, China liufen@bjmu.edu.cn (F.L.); xinshan@bjmu.edu.cn (X.Y.)
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  fullname: Wei, Xingxing
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– sequence: 3
  givenname: Fen
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  fullname: Liu, Fen
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  givenname: Xinshan
  surname: Ye
  fullname: Ye, Xinshan
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  givenname: Decai
  orcidid: 0000-0002-5187-9313
  surname: Xiong
  fullname: Xiong, Decai
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Snippet Glycomimetics, which are synthetic molecules designed to mimic the structures and functions of natural carbohydrates, have been developed to overcome the...
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SubjectTerms Carbohydrates
Cell differentiation
Drug discovery
Fluorides
fluorination
Fluorine
Fluorine compounds
glycomimetics
Metastasis
NMR
Nuclear magnetic resonance
Pharmacokinetics
physical properties
Polysaccharides
Protein binding
Proteins
Reagents
Review
Sugar
synthesis
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Title Drug Discovery Based on Fluorine-Containing Glycomimetics
URI https://www.proquest.com/docview/2869543527
https://www.proquest.com/docview/2870140141
https://pubmed.ncbi.nlm.nih.gov/PMC10536126
https://doaj.org/article/f91c6c777f4b4dca82967523e4ab1972
Volume 28
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