Chronic obstructive lung disease "expert system": validation of a predictive tool for assisting diagnosis

• Published in: International journal of chronic obstructive pulmonary disease Vol. 13; pp. 1747 - 1753
• Main Authors: Braido, Fulvio, Santus, Pierachille, Corsico, Angelo Guido, Di Marco, Fabiano, Melioli, Giovanni, Scichilone, Nicola, Solidoro, Paolo
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.01.2018; Dove Medical Press Ltd; Dove Medical Press
• Subjects: Age Factors; Aged; Asthma; Asthma - complications; Chronic Disease; Chronic Obstructive Lung Diseases; Chronic obstructive pulmonary disease; Cold; Cough - complications; Diagnosis; Dyspnea; Expert Systems; Humans; Lung diseases; Methodology; Middle Aged; Patients; Physicians; Pilot Projects; Primary care; Pulmonary Disease, Chronic Obstructive - complications; Pulmonary Disease, Chronic Obstructive - diagnosis; Questionnaires; Respiratory tract diseases; Sample Size; Software Design; Spirometry; Surveys and Questionnaires; Italy; chronic obstructive lung diseases; diagnosis; expert systems
• ISSN: 1178-2005; 1176-9106; 1178-2005
• DOI: 10.2147/COPD.S165533

The purposes of this study were development and validation of an expert system (ES) aimed at supporting the diagnosis of chronic obstructive lung disease (COLD). A questionnaire and a WebFlex code were developed and validated in silico. An expert panel pilot validation on 60 cases and a clinical validation on 241 cases were performed. The developed questionnaire and code validated in silico resulted in a suitable tool to support the medical diagnosis. The clinical validation of the ES was performed in an academic setting that included six different reference centers for respiratory diseases. The results of the ES expressed as a score associated with the risk of suffering from COLD were matched and compared with the final clinical diagnoses. A set of 60 patients were evaluated by a pilot expert panel validation with the aim of calculating the sample size for the clinical validation study. The concordance analysis between these preliminary ES scores and diagnoses performed by the experts indicated that the accuracy was 94.7% when both experts and the system confirmed the COLD diagnosis and 86.3% when COLD was excluded. Based on these results, the sample size of the validation set was established in 240 patients. The clinical validation, performed on 241 patients, resulted in ES accuracy of 97.5%, with confirmed COLD diagnosis in 53.6% of the cases and excluded COLD diagnosis in 32% of the cases. In 11.2% of cases, a diagnosis of COLD was made by the experts, although the imaging results showed a potential concomitant disorder. The ES presented here (COLD ) is a safe and robust supporting tool for COLD diagnosis in primary care settings.