Cancer as a Ferrotoxic Disease: Are We Getting Hard Stainless Evidence?

• Published in: JNCI : Journal of the National Cancer Institute Vol. 100; no. 14; pp. 976 - 977
• Main Authors: Edgren, Gustaf, Nyrén, Olof, Melbye, Mads
• Format: Journal Article
• Language: English
• Published: Cary, NC Oxford University Press 16.07.2008; Oxford Publishing Limited (England)
• Subjects: Animals; Biological and medical sciences; Biomarkers; Cancer; Carcinogenesis, carcinogens and anticarcinogens; Carcinogens - toxicity; Dietary minerals; DNA Damage; Foods and miscellaneous; Hemochromatosis - complications; Humans; Iron; Iron Compounds - adverse effects; Life Style; Lipid Peroxidation; Liver Neoplasms - etiology; Medical sciences; Medicin och hälsovetenskap; Multicenter Studies as Topic; Neoplasms - chemically induced; Neoplasms - epidemiology; Observer Variation; Oncology; Oxidative Stress; Randomized Controlled Trials as Topic - methods; Research Design; Tumors; Human; Carcinogen; Cancerology; Toxicity; Iron; Malignant tumor; Inorganic element; Carcinogenesis; Cancer
• ISSN: 0027-8874; 1460-2105; 1460-2105
• DOI: 10.1093/jnci/djn225

More studies are needed to clarify the role of iron in carcinogenesis and to concentrate on whether iron depletion may lower the incidence of cancer, slow tumor growth, or perhaps even both. Even if adequate iron therapy, intravenous or oral, should not be withheld where indicated, a cautious standpoint toward iron supplementation where no proper indication exists is perhaps advisable.