Two-Photon Fluorescent Probes for Amyloid-β Plaques Imaging In Vivo

Amyloid-β (Aβ) peptide deposition, hyperphosphorylated tau proteins, reactive astrocytes, high levels of metal ions, and upregulated monoamine oxidases are considered to be the primary pathological markers of Alzheimer’s disease (AD). Among them, Aβ peptide deposition or Aβ plaques, is regarded as t...

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Bibliographic Details
Published inMolecules (Basel, Switzerland) Vol. 28; no. 17; p. 6184
Main Author Chen, Yi
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 22.08.2023
MDPI
Subjects
Advertising executives
Alzheimer's disease
Amyloid beta-protein
Aβ plaques
Biomarkers
Blood vessels
fluorescence probe
in vivo
Investigations
Localization
Microscopy
Review
Three dimensional imaging
Tomography
two-photon imaging
Congo (Kinshasa)
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Summary:Amyloid-β (Aβ) peptide deposition, hyperphosphorylated tau proteins, reactive astrocytes, high levels of metal ions, and upregulated monoamine oxidases are considered to be the primary pathological markers of Alzheimer’s disease (AD). Among them, Aβ peptide deposition or Aβ plaques, is regarded as the initial factor in the pathogenesis of AD and a critical pathological hallmark in AD. This review highlights recently Aβ-specific fluorescent probes for two-photon imaging of Aβ plaques in vivo. It includes the synthesis and detection mechanism of probes, as well as their application to two-photon imaging of Aβ plaques in vivo.
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ISSN:1420-3049
1420-3049
DOI:10.3390/molecules28176184