Prognostic value of preoperative inflammatory response biomarkers in patients with esophageal cancer who undergo a curative thoracoscopic esophagectomy

• Published in: BMC surgery Vol. 16; no. 1; p. 66
• Main Authors: Hirahara, Noriyuki, Matsubara, Takeshi, Mizota, Yoko, Ishibashi, Shuichi, Tajima, Yoshitsugu
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 20.09.2016; BioMed Central
• Subjects: Age Factors; Aged; Aged, 80 and over; Biological markers; Biomarkers - blood; Blood Cell Count; Cancer patients; Carcinoma, Squamous Cell - blood; Carcinoma, Squamous Cell - mortality; Carcinoma, Squamous Cell - surgery; Care and treatment; Diagnosis; Esophageal cancer; Esophageal Neoplasms - blood; Esophageal Neoplasms - mortality; Esophageal Neoplasms - surgery; Esophagectomy; Female; Health aspects; Humans; Lymphocytes; Male; Middle Aged; Multivariate Analysis; Prognosis; Retrospective Studies; Thoracoscopy; Lymphocyte to monocyte ratio (LMR); Platelet lymphocyte ratio (PLR); Neutrophil to lymphocyte ratio (NLR); Prognostic predictor; Esophageal cancer
• ISSN: 1471-2482; 1471-2482
• DOI: 10.1186/s12893-016-0179-5

Several inflammatory response biomarkers, including lymphocyte-to-monocyte ratio (LMR), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) have been reported to predict survival in various cancers. The aim of this study is to evaluate the clinical value of these biomarkers in patients undergoing curative resection for esophageal cancer. The LMR, NLR and PLR were calculated in 147 consecutive patients who underwent esophagectomy between January 2006 and February 2015. We examined the prognostic significance of the LMR, NLR, and PLR in both elderly and non-elderly patients. We evaluated the cancer-specific survival (CSS), with the cause of death determined from the case notes or computerized records. Univariate analyses demonstrated that TNM pStage (p < 0.0001), tumor size (p = 0.0014), operation time (p = 0.0209), low LMR (p = 0.0008), and high PLR (p = 0.0232) were significant risk factors for poor prognosis. Meanwhile, TNM pStage (p < 0.0001) and low LMR (p = 0.0129) were found to be independently associated with poor prognosis via multivariate analysis. In non-elderly patients, univariate analyses demonstrated that TNM pStage (p < 0.0001), tumor size (p = 0.0001), operation time (p = 0.0374), LMR (p < 0.0001), and PLR (p = 0.0189) were significantly associated with a poorer prognosis. Multivariate analysis demonstrated that TNM pStage (p = 0.001) and LMR (p = 0.0007) were independent risk factors for a poorer prognosis. In elderly patients, univariate analysis demonstrated that that TNM pStage (p = 0.0023) was the only significant risk factor for a poor prognosis. LMR was associated with cancer-specific survival (CSS) of esophageal cancer patients after curative esophagectomy. In particular, a low LMR was a significant and independent predictor of poor survival in non-elderly patients. The LMR was convenient, cost effective, and readily available, and could thus act as markers of survival in esophageal cancer.