Activation of group 2 innate lymphoid cells: A new role for cysteinyl leukotrienes

[...]the capacity of LTD4, but not IL-33, to elicit the generation of large quantities of IL-4 by ILC2s suggests a potential link to the TH2-priming functions of the CysLTs in mouse models of allergen-induced pulmonary inflammation.23,38 Third, CysLTs generated by tissue-resident innate immune cells...

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Published inJournal of allergy and clinical immunology Vol. 132; no. 1; pp. 214 - 216
Main Authors Barrett, Nora A., MD, Boyce, Joshua A., MD
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.07.2013
Elsevier Limited
Subjects
Allergies
Allergy and Immunology
Animals
asthma
Cysteinyl leukotrienes
Cytokines - biosynthesis
Disease
Female
group 2 innate lymphoid cells
Immune system
Infections
Lung - immunology
Male
Population
Receptors, Leukotriene - physiology
Rodents
Smooth muscle
Studies
Th2 Cells - immunology
group 2 innate lymphoid cells
Cysteinyl leukotrienes
asthma
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Summary:[...]the capacity of LTD4, but not IL-33, to elicit the generation of large quantities of IL-4 by ILC2s suggests a potential link to the TH2-priming functions of the CysLTs in mouse models of allergen-induced pulmonary inflammation.23,38 Third, CysLTs generated by tissue-resident innate immune cells (dendritic cells, mast cells, and macrophages) in response to natural allergens might contribute not only to breaking tolerance and activating the adaptive immune response but also to driving pathology that is independent of adaptive immunity.
Bibliography:SourceType-Other Sources-1
content type line 63
ObjectType-Editorial-2
ObjectType-Commentary-1
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2013.05.019