Bioorthogonal-targeted 1064 nm excitation theranostic nanoplatform for precise NIR-IIa fluorescence imaging guided efficient NIR-II photothermal therapy

• Published in: Biomaterials Vol. 243; p. 119934
• Main Authors: Zhang, Wansu, Deng, Weixing, Zhang, Hua, Sun, Xiaoli, Huang, Ting, Wang, Wenjun, Sun, Pengfei, Fan, Quli, Huang, Wei
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.06.2020
• Subjects: Animals; biocompatible materials; Bioorthogonal labelling; dyes; fluorescence; Nanoparticles; neoplasms; NIR-II photothermal therapy; NIR-IIa fluorescence imaging; Optical Imaging; Phototherapy; Photothermal Therapy; photothermotherapy; Polymers; Precision Medicine; semiconductors; Theranostic Nanomedicine; Theranostic nanoplatform; NIR-II photothermal therapy; Theranostic nanoplatform; NIR-IIa fluorescence imaging; Precision medicine; Bioorthogonal labelling
• ISSN: 0142-9612; 1878-5905; 1878-5905
• DOI: 10.1016/j.biomaterials.2020.119934

Application of 1064 nm activatable NIR-IIa fluorescence imaging (FI) and NIR-II photothermal therapy (PTT) results in high-resolution imaging and good deep-tissue therapy, respectively. Combining NIR-IIa FI with NIR-II PTT may allow precise diagnosis guided efficient treatment of deep-tissue tumors. However, designing a 1064 activatable theranostic nanoplatform using a single dye for both NIR-IIa FI and NIR-II PTT is a challenge. Herein, we synthesized squaraine-based semiconducting polymer nanoparticles (PSQPNs-DBCO) that were excited by a 1064 nm laser for precise NIR-IIa fluorescence imaging guided NIR-II PTT treatment. Combined with bioorthogonal labeling technology, the PSQPNs-DBCO largely accumulated in the tumor section, extremely enhancing signal-to-background ratio (SBR) of imaging and NIR-II PTT efficiency of tumor in live colorectal-bearing animals. [Display omitted]