Impact of Nutrition on Age-Related Epigenetic RNA Modifications in Rats

Nutrition plastically modulates the epigenetic landscape in various tissues of an organism during life via epigenetic changes. In the present study, to clarify whether this modulation involves RNA methylation, we evaluated global RNA methylation profiles and the expression of writer, reader, and era...

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Published inNutrients Vol. 14; no. 6; p. 1232
Main Authors D'Aquila, Patrizia, De Rango, Francesco, Paparazzo, Ersilia, Mandalà, Maurizio, Bellizzi, Dina, Passarino, Giuseppe
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 15.03.2022
MDPI
Subjects
Adenosine
Aging
Animals
Cell cycle
Diet
DNA Methylation
Enzymes
Epigenesis, Genetic
Epigenetics
Epigenomics
Gene expression
Genes
Hypocaloric diet
Laboratory animals
Life span
Liver
low-calorie diet
Metabolism
Metabolites
Nutrient deficiency
Nutrition
Nutrition research
Nutritional Status
Rats
RNA - genetics
RNA methylation
RNA-protein interactions
tissue-specificity
Tissues
writer
Italy
nutrition
biomarkers
aging
writer
eraser and reader enzymes
RNA methylation
low-calorie diet
tissue-specificity
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Abstract Nutrition plastically modulates the epigenetic landscape in various tissues of an organism during life via epigenetic changes. In the present study, to clarify whether this modulation involves RNA methylation, we evaluated global RNA methylation profiles and the expression of writer, reader, and eraser genes, encoding for enzymes involved in the RNA methylation. The study was carried out in the heart, liver, and kidney samples from rats of different ages in response to a low-calorie diet. We found that, although each tissue showed peculiar RNA methylation levels, a general increase in these levels was observed throughout the lifespan as well as in response to the six-month diet. Similarly, a prominent remodeling of the expression of writer, reader, and eraser genes emerged. Our data provide a comprehensive overview of the role exerted by diet on the tissue-specific epigenetic plasticity of RNA according to aging in rats, providing the first evidence that methylation of RNA, similarly to DNA methylation, can represent an effective biomarker of aging. What is more, the fact that it is regulated by nutrition provides the basis for the development of targeted approaches capable of guaranteeing the maintenance of a state of good health.
AbstractList Nutrition plastically modulates the epigenetic landscape in various tissues of an organism during life via epigenetic changes. In the present study, to clarify whether this modulation involves RNA methylation, we evaluated global RNA methylation profiles and the expression of writer, reader, and eraser genes, encoding for enzymes involved in the RNA methylation. The study was carried out in the heart, liver, and kidney samples from rats of different ages in response to a low-calorie diet. We found that, although each tissue showed peculiar RNA methylation levels, a general increase in these levels was observed throughout the lifespan as well as in response to the six-month diet. Similarly, a prominent remodeling of the expression of writer, reader, and eraser genes emerged. Our data provide a comprehensive overview of the role exerted by diet on the tissue-specific epigenetic plasticity of RNA according to aging in rats, providing the first evidence that methylation of RNA, similarly to DNA methylation, can represent an effective biomarker of aging. What is more, the fact that it is regulated by nutrition provides the basis for the development of targeted approaches capable of guaranteeing the maintenance of a state of good health.
Author Bellizzi, Dina
De Rango, Francesco
Mandalà, Maurizio
D'Aquila, Patrizia
Paparazzo, Ersilia
Passarino, Giuseppe
AuthorAffiliation Department of Biology, Ecology and Earth Science, University of Calabria, 87036 Rende, Italy; patrizia.daquila@unical.it (P.D.); francesco.derango@unical.it (F.D.R.); ersilia.paparazzo@unical.it (E.P.); m.mandala@unical.it (M.M.); giuseppe.passarino@unical.it (G.P.)
AuthorAffiliation_xml – name: Department of Biology, Ecology and Earth Science, University of Calabria, 87036 Rende, Italy; patrizia.daquila@unical.it (P.D.); francesco.derango@unical.it (F.D.R.); ersilia.paparazzo@unical.it (E.P.); m.mandala@unical.it (M.M.); giuseppe.passarino@unical.it (G.P.)
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Issue 6
Keywords nutrition
biomarkers
aging
writer
eraser and reader enzymes
RNA methylation
low-calorie diet
tissue-specificity
Language English
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Snippet Nutrition plastically modulates the epigenetic landscape in various tissues of an organism during life via epigenetic changes. In the present study, to clarify...
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SubjectTerms Adenosine
Aging
Animals
Cell cycle
Diet
DNA Methylation
Enzymes
Epigenesis, Genetic
Epigenetics
Epigenomics
Gene expression
Genes
Hypocaloric diet
Laboratory animals
Life span
Liver
low-calorie diet
Metabolism
Metabolites
Nutrient deficiency
Nutrition
Nutrition research
Nutritional Status
Rats
RNA - genetics
RNA methylation
RNA-protein interactions
tissue-specificity
Tissues
writer
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Title Impact of Nutrition on Age-Related Epigenetic RNA Modifications in Rats
URI https://www.ncbi.nlm.nih.gov/pubmed/35334889
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Volume 14
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