Bronchocentric mycosis occurring in transplant recipients

Although a variety of long-term, probably immunologically induced pulmonary changes have been described in recipients of both combined heart-lung and bone marrow transplantation, pulmonary infections continue to remain causes of significant morbidity and mortality as well. Herein we describe three p...

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Bibliographic Details
Published inChest Vol. 96; no. 1; p. 92
Main Authors Tazelaar, H D, Baird, A M, Mill, M, Grimes, M M, Schulman, L L, Smith, C R
Format Journal Article
LanguageEnglish
Published United States 01.07.1989
Subjects
Adult
Aspergillosis, Allergic Bronchopulmonary - etiology
Bone Marrow Transplantation
Bronchi - pathology
Granuloma - pathology
Heart Transplantation
Humans
Immune Tolerance
Lung Transplantation
Male
Mucormycosis - etiology
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Summary:Although a variety of long-term, probably immunologically induced pulmonary changes have been described in recipients of both combined heart-lung and bone marrow transplantation, pulmonary infections continue to remain causes of significant morbidity and mortality as well. Herein we describe three patients (two heart-lung and one bone marrow transplant recipient) who had bronchocentric granulomatous mycosis, a tissue manifestation of fungal infection not previously described in the setting of a transplant host. Although one patient was being treated successfully with antifungal agents for his mucormycosis, two other patients eventually died of invasive aspergillosis. This emphasizes that although this process is histologically somewhat similar to bronchocentric granulomatosis, a high index of suspicion for infection needs to be maintained when this pathologic process is identified in a transplant host.
ISSN:0012-3692
DOI:10.1378/chest.96.1.92