Raised serum levels of IGFBP-1 and IGFBP-2 in idiopathic pulmonary fibrosis

• Published in: BMC pulmonary medicine Vol. 16; no. 1; p. 86
• Main Authors: Guiot, J., Bondue, B., Henket, M., Corhay, J. L., Louis, R.
• Format: Journal Article Web Resource
• Language: English
• Published: England BioMed Central Ltd 23.05.2016; BioMed Central
• Subjects: Aged; Aged, 80 and over; Analysis; Belgium; Biomarkers - blood; Cardiovascular & respiratory systems; Care and treatment; Case-Control Studies; Diagnosis; Enzyme-Linked Immunosorbent Assay; Female; Human health sciences; Humans; Idiopathic pulmonary fibrosis; Idiopathic Pulmonary Fibrosis - blood; Idiopathic Pulmonary Fibrosis - drug therapy; Indoles - therapeutic use; Influence; Insulin like growth factor binding proteins; Insulin-Like Growth Factor Binding Protein 1 - blood; Insulin-Like Growth Factor Binding Protein 2 - blood; Insuline-like growth factors; Male; Middle Aged; Mucin-1 - blood; Physiology, Pathological; Prospective Studies; Pulmonary fibrosis; Pulmonology; Pyridones - therapeutic use; Sciences de la santé humaine; Systèmes cardiovasculaire & respiratoire; Transforming growth factors; Belgium; Insulin like growth factor binding proteins; Pulmonary fibrosis; Insuline-like growth factors; Idiopathic pulmonary fibrosis
• ISSN: 1471-2466; 1471-2466
• DOI: 10.1186/s12890-016-0249-6

Idiopathic pulmonary fibrosis (IPF) is a chronic lung disorder of unknown origin, which ultimately leads to death. Several growth factors such as IGFs (insulin-like-growth factor) and IGFBPs (insulin like growth factor binding proteins) seem to take part to the pathogenesis. We evaluated IGFs and IGFBPs in serum from patients with IPF and healthy subjects including 24 untreated IPF and 26 IPF receiving anti-fibrotic therapy and to compare them with healthy subjects. Serum of 50 idiopathic pulmonary fibrosis and 55 healthy subjects (HS) were analysed by ELISA for IGFs and IGFBPs, TGF-β and KL-6, the latter being tested as positive control in IPF. Serum levels of IGFBP-1 and IGFBP-2 and KL-6 were significantly higher in the IPF group than in the healthy subjects (p < 0.05, p < 0.001 and p < 0.0001 respectively) while the picture was inversed regarding IGFs. By contrast there was no significant difference between the groups with respect to TGF-β. IGFBP-2 was significantly reduced in the patients with specific anti-fibrotic therapy pirfenidone and nintedanib compared to untreated patients (p < 0.05) but still significantly elevated in comparison to HS (p < 0.001). Serum IGFBP-1 and -2 are increased in idiopathic pulmonary fibrosis and IGFBP-2 may be reduced by anti-fibrosing therapy. IGFBPs may be promising biomarkers in IPF.