New meroterpenoids from the endophytic fungus Aspergillus flavipes AIL8 derived from the mangrove plant Acanthus ilicifolius

Four new meroterpenoids (2-5), along with three known analogues (1, 6, and 7) were isolated from mangrove plant Acanthus ilicifolius derived endophytic fungus Aspergillus flavipes. The structures of these compounds were elucidated by NMR and MS analysis, the configurations were assigned by CD data,...

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Published inMarine drugs Vol. 13; no. 1; pp. 237 - 248
Main Authors Bai, Zhi-Qiang, Lin, Xiuping, Wang, Junfeng, Zhou, Xuefeng, Liu, Juan, Yang, Bin, Yang, Xianwen, Liao, Shengrong, Wang, Lishu, Liu, Yonghong
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 07.01.2015
MDPI
Subjects
Acanthaceae - microbiology
Acanthus ilicifolius
Aspergillus - chemistry
Aspergillus flavipes
Crystallography, X-Ray
endophytic fungus
Magnetic Resonance Spectroscopy
Marine
Mass Spectrometry
meroterpenoid
Molecular Structure
Terpenes - chemistry
Terpenes - isolation & purification
Terpenes - metabolism
Wetlands
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Summary:Four new meroterpenoids (2-5), along with three known analogues (1, 6, and 7) were isolated from mangrove plant Acanthus ilicifolius derived endophytic fungus Aspergillus flavipes. The structures of these compounds were elucidated by NMR and MS analysis, the configurations were assigned by CD data, and the stereochemistry of 1 was confirmed by X-ray crystallography analysis. A possible biogenetic pathway of compounds 1-7 was also proposed. All compounds were evaluated for antibacterial and cytotoxic activities.
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These authors contributed equally to this paper.
ISSN:1660-3397
1660-3397
DOI:10.3390/md13010237