The new Bruch's membrane opening - minimum rim width classification improves optical coherence tomography specificity in tilted discs

• Published in: Clinical ophthalmology (Auckland, N.Z.) Vol. 10; pp. 2417 - 2425
• Main Authors: Rebolleda, Gema, Casado, Alfonso, Oblanca, Noelia, Muñoz-Negrete, Francisco J
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.01.2016; Taylor & Francis Ltd; Dove Medical Press
• Subjects: Automation; Bruch membrane; false-positive; Glaucoma; Medical imaging; Ophthalmology; optical coherence tomography; Optics; Original Research; tilted disc; Tomography; Germany; tilted disc; Bruch membrane; optical coherence tomography; false-positive
• ISSN: 1177-5467; 1177-5483; 1177-5483
• DOI: 10.2147/OPTH.S120237

To investigate and compare the false-positive (FP) diagnostic classification of the Bruch's membrane opening - minimum rim width (BMO-MRW) and retinal nerve fiber layer (RNFL) thickness in healthy eyes with tilted optic disc. Fifty healthy eyes of 30 participants with tilted optic disc underwent BMO-MRW and RNFL scanning using Spectralis and macular Cirrus optical coherence tomography (OCT) scans. The overall FP rate was significantly lower using BMO-MRW map compared with both RNFL map by Spectralis (8% vs 62%, respectively, <0.001) and ganglion cell analysis (GCA) map by Cirrus (8% vs 50%, respectively, <0.001). Specificity was significantly higher using BMO-MRW than RNFL in eyes with low (89.7% vs 41.4%, <0.001) and moderate myopia (95.2% vs 33.3%, <0.001). OCT-derived BMO-MRW analysis provides significantly greater specificity than RNFL in tilted disc irrespectively of the refractive error, and it is more specific than GCA analysis in tilted disc with moderate myopia.