A Review Study on Macrolides Isolated from Cyanobacteria

Cyanobacteria are rich sources of structurally-diverse molecules with promising pharmacological activities. Marine cyanobacteria have been proven to be true producers of some significant bioactive metabolites from marine invertebrates. Macrolides are a class of bioactive compounds isolated from mari...

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Published inMarine drugs Vol. 15; no. 5; p. 126
Main Authors Wang, Mengchuan, Zhang, Jinrong, He, Shan, Yan, Xiaojun
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 26.04.2017
MDPI
Subjects
Animals
Antibiotics
Aquatic Organisms - chemistry
Bioactive compounds
bioactivity
Biocompatibility
Biological Factors - chemistry
Biological Factors - pharmacology
Biomedical materials
Carbon
Chlorination
Cyanobacteria
Cyanobacteria - chemistry
Data
Humans
Invertebrates
macrolides
Macrolides - chemistry
Macrolides - pharmacology
Marine invertebrates
Marine microorganisms
Marine organisms
Metabolites
Microorganisms
Pharmacology
Review
Reviews
secondary metabolites
Structure-Activity Relationship
Structures
Surgical implants
macrolides
secondary metabolites
bioactivity
cyanobacteria
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Abstract Cyanobacteria are rich sources of structurally-diverse molecules with promising pharmacological activities. Marine cyanobacteria have been proven to be true producers of some significant bioactive metabolites from marine invertebrates. Macrolides are a class of bioactive compounds isolated from marine organisms, including marine microorganisms in particular. The structural characteristics of macrolides from cyanobacteria mainly manifest in the diversity of carbon skeletons, complexes of chlorinated thiazole-containing molecules and complex spatial configuration. In the present work, we systematically reviewed the structures and pharmacological activities of macrolides from cyanobacteria. Our data would help establish an effective support system for the discovery and development of cyanobacterium-derived macrolides.
AbstractList Cyanobacteria are rich sources of structurally-diverse molecules with promising pharmacological activities. Marine cyanobacteria have been proven to be true producers of some significant bioactive metabolites from marine invertebrates. Macrolides are a class of bioactive compounds isolated from marine organisms, including marine microorganisms in particular. The structural characteristics of macrolides from cyanobacteria mainly manifest in the diversity of carbon skeletons, complexes of chlorinated thiazole-containing molecules and complex spatial configuration. In the present work, we systematically reviewed the structures and pharmacological activities of macrolides from cyanobacteria. Our data would help establish an effective support system for the discovery and development of cyanobacterium-derived macrolides.
Author He, Shan
Wang, Mengchuan
Yan, Xiaojun
Zhang, Jinrong
AuthorAffiliation 1 School of Marine Sciences, Laboratory of Marine Natural Products, Ningbo University, Ningbo 315211, China; mengchuanwang1@163.com (M.W.); heshan@nbu.edu.cn (S.H.)
2 Key Laboratory of Applied Marine Biotechnology of Ministry of Education, Ningbo University, Ningbo 315211, China; yanxiaojun@nbu.edu.cn
AuthorAffiliation_xml – name: 1 School of Marine Sciences, Laboratory of Marine Natural Products, Ningbo University, Ningbo 315211, China; mengchuanwang1@163.com (M.W.); heshan@nbu.edu.cn (S.H.)
– name: 2 Key Laboratory of Applied Marine Biotechnology of Ministry of Education, Ningbo University, Ningbo 315211, China; yanxiaojun@nbu.edu.cn
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  surname: Wang
  fullname: Wang, Mengchuan
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  organization: School of Marine Sciences, Laboratory of Marine Natural Products, Ningbo University, Ningbo 315211, China. mengchuanwang1@163.com
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  givenname: Jinrong
  surname: Zhang
  fullname: Zhang, Jinrong
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  surname: Yan
  fullname: Yan, Xiaojun
  email: yanxiaojun@nbu.edu.cn
  organization: Key Laboratory of Applied Marine Biotechnology of Ministry of Education, Ningbo University, Ningbo 315211, China. yanxiaojun@nbu.edu.cn
BackLink https://www.ncbi.nlm.nih.gov/pubmed/28445442$$D View this record in MEDLINE/PubMed
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Issue 5
Keywords macrolides
secondary metabolites
bioactivity
cyanobacteria
Language English
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Snippet Cyanobacteria are rich sources of structurally-diverse molecules with promising pharmacological activities. Marine cyanobacteria have been proven to be true...
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StartPage 126
SubjectTerms Animals
Antibiotics
Aquatic Organisms - chemistry
Bioactive compounds
bioactivity
Biocompatibility
Biological Factors - chemistry
Biological Factors - pharmacology
Biomedical materials
Carbon
Chlorination
Cyanobacteria
Cyanobacteria - chemistry
Data
Humans
Invertebrates
macrolides
Macrolides - chemistry
Macrolides - pharmacology
Marine invertebrates
Marine microorganisms
Marine organisms
Metabolites
Microorganisms
Pharmacology
Review
Reviews
secondary metabolites
Structure-Activity Relationship
Structures
Surgical implants
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Title A Review Study on Macrolides Isolated from Cyanobacteria
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Volume 15
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