A Review Study on Macrolides Isolated from Cyanobacteria

• Published in: Marine drugs Vol. 15; no. 5; p. 126
• Main Authors: Wang, Mengchuan, Zhang, Jinrong, He, Shan, Yan, Xiaojun
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 26.04.2017; MDPI
• Subjects: Animals; Antibiotics; Aquatic Organisms - chemistry; Bioactive compounds; bioactivity; Biocompatibility; Biological Factors - chemistry; Biological Factors - pharmacology; Biomedical materials; Carbon; Chlorination; Cyanobacteria; Cyanobacteria - chemistry; Data; Humans; Invertebrates; macrolides; Macrolides - chemistry; Macrolides - pharmacology; Marine invertebrates; Marine microorganisms; Marine organisms; Metabolites; Microorganisms; Pharmacology; Review; Reviews; secondary metabolites; Structure-Activity Relationship; Structures; Surgical implants; macrolides; secondary metabolites; bioactivity; cyanobacteria
• ISSN: 1660-3397; 1660-3397
• DOI: 10.3390/md15050126

Cyanobacteria are rich sources of structurally-diverse molecules with promising pharmacological activities. Marine cyanobacteria have been proven to be true producers of some significant bioactive metabolites from marine invertebrates. Macrolides are a class of bioactive compounds isolated from marine organisms, including marine microorganisms in particular. The structural characteristics of macrolides from cyanobacteria mainly manifest in the diversity of carbon skeletons, complexes of chlorinated thiazole-containing molecules and complex spatial configuration. In the present work, we systematically reviewed the structures and pharmacological activities of macrolides from cyanobacteria. Our data would help establish an effective support system for the discovery and development of cyanobacterium-derived macrolides.