Limbal Allograft, Amniotic Membrane Transplantation, and Intraoperative Mitomycin C for Recurrent Pterygium

• Published in: Ophthalmology Vol. 112; no. 7; pp. 1263 - 1267
• Main Authors: Miyai, Takashi, Hara, Ryuhei, Nejima, Ryohei, Miyata, Kazunori, Yonemura, Takaharu, Amano, Shiro
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.07.2005; Elsevier BV; Elsevier
• Subjects: Aged; Amnion; Amnion - transplantation; Antibiotics, Antineoplastic; Antibiotics, Antineoplastic - administration & dosage; Biological and medical sciences; Cell Transplantation; Combined Modality Therapy; Diseases of eyelid, conjunctiva and lacrimal tracts; Epithelial Cells; Epithelial Cells - transplantation; Female; Follow-Up Studies; Humans; Intraoperative Care; Intraoperative Care - methods; Limbus Corneae; Limbus Corneae - cytology; Male; Medical sciences; Middle Aged; Mitomycin; Mitomycin - administration & dosage; Ophthalmology; Pilot Projects; Postoperative Complications; Prospective Studies; Pterygium; Pterygium - drug therapy; Pterygium - surgery; Recurrence; Safety; Tissue Preservation; Transplantation, Homologous; Treatment Outcome; Antineoplastic agent; Pterygium; Relapse; Mitomycin; Rim of sclera; Homograft; Transplantation; Conjunctiva disease; Recurrent; Eye disease; Antibiotic; Treatment; Surgery; Graft; Membrane; Ophthalmology
• ISSN: 0161-6420; 1549-4713; 1549-4713
• DOI: 10.1016/j.ophtha.2005.01.037

To conduct a pilot study evaluating the efficacy and safety of limbal allograft, preserved amniotic membrane transplantation, and intraoperative mitomycin C treatment for recurrent pterygium. Prospective, noncomparative, interventional case series. Twelve eyes of 11 patients with recurrent pterygium. The mean number of previous surgeries for pterygium was 1.9±1.4 (range, 1–6). All subjects received limbal allograft, preserved amniotic membrane transplantation, and intraoperative mitomycin C. Pterygium recurrence and complications. The mean follow-up period was 21.6±5.6 months (range, 16–36 months). There was no pterygium recurrence in any of the eyes. Symblepharon reappeared in 3 eyes and diplopia recurred in 2 eyes. There were no other surgical complications and there was no graft rejection. Limbal allograft, preserved amniotic membrane transplantation, and intraoperative mitomycin C may be a safe and effective procedure for recurrent pterygium.