The Use of Cell-free Protein Synthesis to Push the Boundaries of Synthetic Biology

Cell-free protein synthesis is emerging as a powerful tool to accelerate the progress of synthetic biology. Notably, cell-free systems that harness extracted synthetic machinery of cells can address many of the issues associated with the complexity and variability of living systems. In particular, c...

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Bibliographic Details
Published inBiotechnology and bioprocess engineering Vol. 28; no. 6; pp. 922 - 928
Main Authors Kim, Kyu Jae, Lee, So-Jeong, Kim, Dong-Myung
Format Journal Article
LanguageEnglish
Published Seoul The Korean Society for Biotechnology and Bioengineering 01.12.2023
Springer Nature B.V
한국생물공학회
Subjects
Bioengineering
Biology
Biotechnology
cell-free protein synthesis
Cells
Chemistry
Chemistry and Materials Science
Climate change
diagnostic techniques
E coli
Efficiency
Enzymes
Gene expression
Genetic engineering
Genomes
Industrial and Production Engineering
Metabolism
Optimization
Physiology
Polymerase chain reaction
Productivity
Protein biosynthesis
Protein expression
Protein synthesis
Proteins
Review Paper
Synthetic biology
생물공학
recombinant proteins
synthetic biology
metabolic engineering
cell-free protein synthesis
artificial cells
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Summary:Cell-free protein synthesis is emerging as a powerful tool to accelerate the progress of synthetic biology. Notably, cell-free systems that harness extracted synthetic machinery of cells can address many of the issues associated with the complexity and variability of living systems. In particular, cell-free systems can be programmed with various configurations of genetic information, providing great flexibility and accessibility to the field of synthetic biology. Empowered by recent progress, cell-free systems are now evolving into artificial biological systems that can be tailored for various applications, including on-demand biomanufacturing, diagnostics, and new materials design. Here, we review the key developments related to cell-free protein synthesis systems, and discuss the future directions of these promising technologies.
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ISSN:1226-8372
1976-3816
DOI:10.1007/s12257-022-0279-2