The GSTP1 gene variant rs1695 is not associated with an increased risk of multiple sclerosis

• Published in: Cellular & molecular immunology Vol. 12; no. 6; pp. 777 - 779
• Main Authors: Agúndez, José A G, García-Martín, Elena, Martínez, Carmen, Benito-León, Julián, Millán-Pascual, Jorge, Díaz-Sánchez, María, Calleja, Patricia, Pisa, Diana, Turpín-Fenoll, Laura, Alonso-Navarro, Hortensia, Ayuso-Peralta, Lucía, Torrecillas, Dolores, García-Albea, Esteban, Plaza-Nieto, José Francisco, Jiménez-Jiménez, Félix Javier
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.11.2015; Nature Publishing Group
• Subjects: Adult; Alleles; Antibodies; Biomedical and Life Sciences; Biomedicine; Case-Control Studies; Female; Gene Expression; Gene Frequency; Genome-Wide Association Study; Genotype; Glutathione S-Transferase pi - genetics; Glutathione S-Transferase pi - metabolism; Glutathione transferase; Humans; Immunology; Male; Medical Microbiology; Microbiology; Middle Aged; Multiple sclerosis; Multiple Sclerosis - genetics; Multiple Sclerosis - metabolism; Multiple Sclerosis - pathology; NAD(P)H Dehydrogenase (Quinone) - genetics; NAD(P)H Dehydrogenase (Quinone) - metabolism; P1基因; Phenotype; Polymorphism, Single Nucleotide; Risk; Short Communication; Vaccine; 临床类型; 单核苷酸多态性; 基因变异; 基因型频率; 多发性硬化; 谷胱甘肽S-转移酶; 风险
• ISSN: 1672-7681; 2042-0226
• DOI: 10.1038/cmi.2014.121

We analyzed the allelic and genotypic frequencies of the glutathione-S-transferase P1 （GSTPI） rs1695 single nucleotide polymorphism （SNP） in 290 patients with multiple sclerosis （MS） and in 310 healthy controls. We found no significant association between the rs1695 variant and MS. Among MS patients, there was no relationship between the rs1695 variant and either gender, clinical type of MS or the age of onset of MS.