Microfluidic Technology for Clinical Applications of Exosomes

Exosomes, a type of nanovesicle, are distinct cellular entities specifically capable of carrying various cargos between cells. It has been hypothesized that exosomes, as an enriched source of biomolecules, may serve as biomarkers for various diseases. This review introduces general aspects of exosom...

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Published inMicromachines (Basel) Vol. 10; no. 6; p. 392
Main Authors Iliescu, Florina S, Vrtačnik, Danilo, Neuzil, Pavel, Iliescu, Ciprian
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 12.06.2019
MDPI
Subjects
Arthritis
Biomarkers
Biomolecules
Biopsy
Cancer
clinical applications
Communication
exosomes
extracellular vesicles
Homeostasis
inflammation
Laboratory animals
Lipids
Microfluidics
Physiology
Proteins
Review
T cell receptors
cancer
extracellular vesicles
clinical applications
inflammation
microfluidics
exosomes
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Summary:Exosomes, a type of nanovesicle, are distinct cellular entities specifically capable of carrying various cargos between cells. It has been hypothesized that exosomes, as an enriched source of biomolecules, may serve as biomarkers for various diseases. This review introduces general aspects of exosomes, presents the challenges in exosome research, discusses the potential of exosomes as biomarkers, and describes the contribution of microfluidic technology to enable their isolation and analysis for diagnostic and disease monitoring. Additionally, clinical applications of exosomes for diagnostic purposes are also summarized.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
ISSN:2072-666X
2072-666X
DOI:10.3390/mi10060392