Thrombotic thrombocytopenic purpura associated with dengue and chikungunya virus coinfection: case report during an epidemic period

The present report shows the occurrence of thrombotic thrombocytopenic purpura (TTP) associated with acute dengue and chikungunya virus coinfection, manifesting as a severe disease with high mortality potential. The patient was a 28 year-old man with clinical and epidemiological diagnosis of arbovir...

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Published inRevista do Instituto de Medicina Tropical de São Paulo Vol. 60; pp. e48 - 4
Main Authors Bastos, Maria Luiza Almeida, Araújo, Ruth Maria Oliveira de, Oliveira, Deivide de Sousa, Cavalcante, Ana Nery Melo, Silva Junior, Geraldo Bezerra da
Format Journal Article
LanguageEnglish
Portuguese
Published Brazil Instituto de Medicina Tropical de Sao Paulo 01.01.2018
Instituto de Medicina Tropical
Universidade de São Paulo (USP)
Subjects
Acute Disease
Adult
Case Report
Chikungunya Fever - complications
Chikungunya virus
Coinfection
Dengue - complications
Dengue virus
Humans
Male
Purpura, Thrombotic Thrombocytopenic - diagnosis
Purpura, Thrombotic Thrombocytopenic - virology
Thrombotic thrombocytopenic purpura
TROPICAL MEDICINE
Thrombotic thrombocytopenic purpura
Coinfection
Dengue virus
Chikungunya virus
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Summary:The present report shows the occurrence of thrombotic thrombocytopenic purpura (TTP) associated with acute dengue and chikungunya virus coinfection, manifesting as a severe disease with high mortality potential. The patient was a 28 year-old man with clinical and epidemiological diagnosis of arboviruses infections who developed thrombocytopenia and anemia, after which oral corticosteroid therapy was started. On the third day of hospitalization, he showed neurological alterations that simulated a cerebral vascular accident, but the imaging examination did not identify ischemic or hemorrhagic alterations. At that moment, the TTP hypothesis was raised so that plasmapheresis and corticosteroid pulse therapy were started, have been essential for the favorable evolution of the case.
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There are no conflicts of interest between the investigators and the patient, who authorized the reporting of his case by signing the free and informed consent form.
CONFLICT OF INTEREST
ISSN:1678-9946
0036-4665
1678-9946
DOI:10.1590/S1678-9946201860048